{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:02:31Z","timestamp":1753869751019,"version":"3.41.2"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T00:00:00Z","timestamp":1598313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shire Development LLC, a member of the Takeda group of companies"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Methods Psych Res"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study examined Sheehan Disability Scale (SDS) performance in binge eating disorder (BED) and explored relationships between SDS and BED outcomes using data from three placebo\u2010controlled lisdexamfetamine (LDX) studies (two short\u2010term, dose\u2010optimized studies and one double\u2010blind, randomized\u2010withdrawal study) in adults with Diagnostic and Statistical Manual of Mental Disorders, fourth edition, text revision (DSM\u2010IV\u2010TR)\u2013defined BED.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Analyses evaluated the psychometric properties of the SDS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Confirmatory factor analysis supported a unidimensional total score in the short\u2010term studies, with internal consistency (Cronbach's <jats:italic>\u03b1<\/jats:italic>) being 0.878. Total score exhibited good construct validity, with moderate and statistically significant correlations observed with Yale\u2013Brown Obsessive Compulsive Scale modified for binge eating, Binge Eating Scale (BES), and EuroQol Group 5\u2010Dimension 5\u2010Level health status index scores. Known\u2010groups validity analysis for the short\u2010term studies demonstrated a significantly lower total score at end of study in participants considered \u201cnot ill\u201d versus \u201cill\u201d based on Clinical Global Impressions\u2013Severity scores. SDS total score changes in the short\u2010term studies were greater in responders than nonresponders based on binge eating abstinence or BES score. In the randomized\u2010withdrawal study, SDS scores increased relative to baseline to a greater extent in participants randomized to placebo than LDX.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These analyses support the reliability, validity, and responsiveness to change of the SDS in individuals with BED.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mpr.1849","type":"journal-article","created":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T07:00:36Z","timestamp":1598425236000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluating functional disability in clinical trials of lisdexamfetamine dimesylate in binge eating disorder using the Sheehan Disability Scale"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6026-1435","authenticated-orcid":false,"given":"Karen S.","family":"Yee","sequence":"first","affiliation":[{"name":"Shire a Member of the Takeda Group of Companies  Cambridge Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin","family":"Pokrzywinski","sequence":"additional","affiliation":[{"name":"Patient\u2010Centered Research Evidera  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asha","family":"Hareendran","sequence":"additional","affiliation":[{"name":"Patient\u2010Centered Research Evidera  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon","family":"Shaffer","sequence":"additional","affiliation":[{"name":"Patient\u2010Centered Research Evidera  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David V.","family":"Sheehan","sequence":"additional","affiliation":[{"name":"University of South Florida College of Medicine  Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,25]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_1_2_1","DOI":"10.1016\/j.psychres.2007.11.018"},{"volume-title":"Statistical power analysis for the behavioral sciences","year":"1988","author":"Cohen J.","key":"e_1_2_8_1_3_1"},{"key":"e_1_2_8_1_4_1","first-page":"887","article-title":"Psychometric evaluation of the Sheehan Disability Scale in adult patients with attention\u2010deficit\/hyperactivity disorder","volume":"10","author":"Coles T.","year":"2014","journal-title":"Neuropsychiatric Disease and Treatment"},{"doi-asserted-by":"publisher","key":"e_1_2_8_1_5_1","DOI":"10.1002\/eat.22407"},{"doi-asserted-by":"publisher","key":"e_1_2_8_1_6_1","DOI":"10.1016\/0306-4603(82)90024-7"},{"volume-title":"Clinical global impression (CGI)","year":"1976","author":"Guy W.","key":"e_1_2_8_1_7_1"},{"doi-asserted-by":"publisher","key":"e_1_2_8_1_8_1","DOI":"10.1007\/s11136-011-9903-x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_1_9_1","DOI":"10.1001\/jamapsychiatry.2017.1889"},{"doi-asserted-by":"publisher","key":"e_1_2_8_1_10_1","DOI":"10.4088\/JCP.14m09335"},{"doi-asserted-by":"publisher","key":"e_1_2_8_1_11_1","DOI":"10.1007\/s11136-012-0322-4"},{"doi-asserted-by":"publisher","key":"e_1_2_8_1_12_1","DOI":"10.1017\/S0033291701004640"},{"doi-asserted-by":"publisher","key":"e_1_2_8_1_13_1","DOI":"10.1016\/j.biopsych.2012.11.020"},{"doi-asserted-by":"publisher","key":"e_1_2_8_1_14_1","DOI":"10.2190\/T8EM-C8YH-373N-1UWD"},{"doi-asserted-by":"publisher","key":"e_1_2_8_1_15_1","DOI":"10.1007\/BF00788510"},{"doi-asserted-by":"publisher","key":"e_1_2_8_1_16_1","DOI":"10.1016\/0306-4603(85)90022-X"},{"doi-asserted-by":"publisher","key":"e_1_2_8_1_17_1","DOI":"10.1038\/npp.2015.275"},{"doi-asserted-by":"publisher","key":"e_1_2_8_1_18_1","DOI":"10.1097\/01.MLR.0000062554.74615.4C"},{"doi-asserted-by":"publisher","key":"e_1_2_8_1_19_1","DOI":"10.1016\/j.jclinepi.2007.03.012"},{"volume-title":"Handbook of psychiatric measures","year":"2008","author":"Rush A. 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