{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T23:00:00Z","timestamp":1793746800882,"version":"4.6.1"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T00:00:00Z","timestamp":1608681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008897","name":"Janssen Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Methods Psych Res"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To explore clinical and demographic characteristics impacting patient functioning by determining extent of overlap in factors driving change in Personal and Social Performance (PSP) and other clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Post\u2010hoc analysis from a single\u2010arm trial of paliperidone extended release in adult patients with nonacute symptomatic schizophrenia. Psychosocial functioning measures: PSP, Clinical Global Impression\u2013Severity (CGI\u2010S), Positive and Negative Syndrome Scale (PANSS), Short\u2010Form 36 (SF\u201036), treatment satisfaction, sleep quality\/daytime drowsiness, and Extrapyramidal Symptoms Rating Scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Highest correlations with PSP total score change included PANSS total score change (Spearman's <jats:italic>r<\/jats:italic> = 0.607), PANSS general psychopathology change (<jats:italic>r<\/jats:italic> = 0.579), and CGI\u2010S change (<jats:italic>r<\/jats:italic> = 0.569). A PSP score change of \u221232 predicted 90% probability of deterioration in CGI\u2010S (score change of \u22651). The power of PSP change to predict PANSS total score change was lower. Linear stepwise regression demonstrated independent relationships for PSP change and: PANSS total change; CGI\u2010S change; SF\u201036 Mental Component change; treatment satisfaction at endpoint; PSP at baseline; previous psychiatric hospitalizations. <jats:italic>R<\/jats:italic>\n<jats:sup>2<\/jats:sup> = 0.55 meant that 45% of PSP variation could not be explained by other clinical outcome measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Psychosocial functioning improvement is important in schizophrenia. PSP may be valuable for assessing functioning; it encompasses psychosocial and clinical factors not measured by other established assessments.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mpr.1855","type":"journal-article","created":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T14:42:09Z","timestamp":1608820929000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Relationship between clinical outcomes measures and personal and social performance functioning in a prospective, interventional study in schizophrenia"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8711-1245","authenticated-orcid":false,"given":"Roland","family":"Vauth","sequence":"first","affiliation":[{"name":"Center for Mental Health Department of Psychiatry and Psychotherapy University Hospital of Psychiatry Basel University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardo","family":"Carpiniello","sequence":"additional","affiliation":[{"name":"Unit of Psychiatry Department of Medical Sciences and Public Health University of Cagliari  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Turczy\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Developmental Psychotic, and Geriatric Psychiatry Medical University of Gda\u0144sk  Gda\u0144sk Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail","family":"Ivanov","sequence":"additional","affiliation":[{"name":"St Petersburg Psychoneurological Research Institute  St Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Cherubin","sequence":"additional","affiliation":[{"name":"Medical Affairs EMEA Janssen\u2010Cilag  Issy\u2010les\u2010Moulineaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjolein","family":"Lahaye","sequence":"additional","affiliation":[{"name":"Medical Affairs EMEA Janssen\u2010Cilag BV  Breda Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Schreiner","sequence":"additional","affiliation":[{"name":"Medical &amp; Scientific Affairs EMEA Janssen\u2010Cilag GmbH  Neuss Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,23]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"American Psychiatric Association. 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