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The aim of this review is to describe the different definitions used and to test these definitions for their accuracy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A narrative PubMed literature review was conducted based on articles published between 1 January 1990 and 31 December 2020 describing benzodiazepines (in MeSH Terms or MeSH Major Topic) and high\u2010dose (or high\u2010dosage). Specific definitions were applied to a population sample to show how definitions affect high\u2010dose benzodiazepine prevalence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multiples of an equivalent\u2010diazepam dose or of the World Health Organization \u2018defined daily dosage\u2019 were used more frequently than the overstep of the recommended maximum therapeutic dosage as a cut\u2010off point.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High\u2010dose use is rare but the prevalence in the general population varies among studies, mainly due to different definitions, making both clinical and epidemiological comparisons between studies difficult. Defining a high\u2010dose user as a person who takes at least a higher dose than the maximum usual therapeutic dose over a defined period of time therefore appears to be clinically more consistent.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mpr.1888","type":"journal-article","created":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T18:25:24Z","timestamp":1627755924000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Benzodiazepine high\u2010doses: The need for an accurate definition"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7655-5155","authenticated-orcid":false,"given":"Jean\u2010Marc","family":"Cloos","sequence":"first","affiliation":[{"name":"Department of Psychiatry H\u00f4pitaux Robert Schuman  Luxembourg Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher Y. 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