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However, the \u201cequal weight\u201d assumption fails to fit PTSD symptom data when tested. The present study developed an enhanced PTSD diagnosis based on (a) a conventional PTSD diagnosis from a clinical interview and (b) an empirical classification of full PTSD that reflected the relative clinical weights of each symptom.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Baseline structured interview data from Project Harmony (<jats:italic>N<\/jats:italic>\u00a0=\u00a02658) was used. An enhanced diagnosis for full PTSD was estimated using an empirical threshold from moderated nonlinear factor analysis (MNLFA) latent PTSD scale scores, in combination with a full conventional PTSD diagnosis based on interview data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One in 4 patients in the sample had a PTSD diagnosis that was inconsistent with their empirical PTSD grouping, such that the enhanced diagnostic standard reduced the diagnostic discrepancy rate by 20%. Veterans, and in particular female Veterans, were at greatest odds for discrepancy between their underlying PTSD severity and DSM diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Psychometric methodologies that differentially weight symptoms can complement DSM criteria and may serve as a platform for symptom prioritization for diagnoses in future editions of DSM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mpr.1963","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T09:53:00Z","timestamp":1676454780000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Differential symptom weighting in estimating empirical thresholds for underlying PTSD severity: Toward a \u201cplatinum\u201d standard for diagnosis?"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4706-9964","authenticated-orcid":false,"given":"Antonio A.","family":"Morgan\u2010L\u00f3pez","sequence":"first","affiliation":[{"name":"Community Health Research Division RTI International  Research Triangle Park North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lissette M.","family":"Saavedra","sequence":"additional","affiliation":[{"name":"Community Health Research Division RTI International  Research Triangle Park North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise A.","family":"Hien","sequence":"additional","affiliation":[{"name":"Center of Alcohol &amp; Substance Use Studies Rutgers University\u2013New Brunswick  Piscataway New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonya B.","family":"Norman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of California  San Diego Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Skye S.","family":"Fitzpatrick","sequence":"additional","affiliation":[{"name":"Department of Psychology York University  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Psychology &amp; Neuroscience L.L. 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