{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T11:06:48Z","timestamp":1778152008127,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T00:00:00Z","timestamp":1693872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["ZIAMH002857"],"award-info":[{"award-number":["ZIAMH002857"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Methods Psych Res"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study explored the potential of non\u2010parametric and complexity analysis metrics to detect changes in activity post\u2010ketamine and their association with depressive symptomatology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Individuals with treatment\u2010resistant depression (TRD: <jats:italic>n<\/jats:italic>\u00a0=\u00a027, 16F, 35.9\u00a0\u00b1\u00a010.8\u00a0years) and healthy volunteers (HVs: <jats:italic>n<\/jats:italic>\u00a0=\u00a09, 4F, 36.4\u00a0\u00b1\u00a09.59\u00a0years) had their activity monitored during an inpatient, double\u2010blind, crossover study where they received an infusion of ketamine or saline placebo. All participants were 18\u201365\u00a0years old, medication\u2010free, and had a MADRS score \u226520. Non\u2010parametric metrics averaged over each study day, metrics derived from complexity analysis, and traditionally calculated non\u2010parametric metrics averaged over two weeks were calculated from the actigraphy time series. A separate analysis was conducted for a subsample (<jats:italic>n<\/jats:italic>\u00a0=\u00a017) to assess the utility of these metrics in a hospital setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In HVs, lower intradaily variability was observed within daily rest\/activity patterns post\u2010ketamine versus post\u2010placebo (<jats:italic>F<\/jats:italic>\u00a0=\u00a05.16(1,15), <jats:italic>p<\/jats:italic>\u00a0=\u00a00.04). No other significant effects of drug or drug\u2010by\u2010time or correlations between depressive symptomatology and activity were detected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Weak associations between non\u2010parametric variables and ketamine were found but were not consistent across actigraphy measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Trial registration<\/jats:title><jats:p>ClinicalTrials.gov, NCT00088699.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mpr.1984","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T12:07:26Z","timestamp":1693915646000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["An exploration of actigraphy in the context of ketamine and treatment\u2010resistant depression"],"prefix":"10.1002","volume":"33","author":[{"given":"Claire","family":"Punturieri","sequence":"first","affiliation":[{"name":"Experimental Therapeutics and Pathophysiology Branch National Institute of Mental Health National Institutes of Health  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Wallace C.","family":"Duncan","sequence":"additional","affiliation":[{"name":"Experimental Therapeutics and Pathophysiology Branch National Institute of Mental Health National Institutes of Health  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dede","family":"Greenstein","sequence":"additional","affiliation":[{"name":"Experimental Therapeutics and Pathophysiology Branch National Institute of Mental Health National Institutes of Health  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gavi","family":"Shandler","sequence":"additional","affiliation":[{"name":"Experimental Therapeutics and Pathophysiology Branch National Institute of Mental Health National Institutes of Health  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Carlos A.","family":"Zarate","sequence":"additional","affiliation":[{"name":"Experimental Therapeutics and Pathophysiology Branch National Institute of Mental Health National Institutes of Health  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7176-5759","authenticated-orcid":false,"given":"Jennifer W.","family":"Evans","sequence":"additional","affiliation":[{"name":"Experimental Therapeutics and Pathophysiology Branch National Institute of Mental Health National Institutes of Health  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,5]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2021.102140"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.31887\/dcns.2016.18.2\/parean"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.07.001"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.2196\/jmir.7006"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145712000545"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.05.042"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2017.03.011"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920\u2010013\u20100394\u2010z"},{"key":"e_1_2_13_10_1","volume-title":"Structured clinical Interview for DSM\u2010IV\u2010TR Axis I disorders, research version","author":"First M. 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