{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:51:44Z","timestamp":1777477904718,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Methods Psych Res"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Anxiety and sleep disorders are common in the population and anxiolytics and sedatives are widely used. Our aim was to describe the drug utilization of new users of anxiolytics and sedatives in adults including type of drug, doses, prescribers' characteristics, and psychiatric comorbidity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A register\u2010based cohort study of new users (18\u201364\u00a0years) of anxiolytics and sedatives in 2015\u20132019, free of any such drug 5\u00a0years prior to inclusion. The individuals were linked to national registers on dispensed drugs and recorded diagnoses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 764,432 new users of anxiolytics and sedatives were identified, which corresponds to an incidence of 26\/1000 inhabitants and year. The proportion of new users of benzodiazepines (including both anxiolytics and sedatives) decreased, whereas the proportion of sedative antihistamines and melatonin increased. The most common drug dispensed was hydroxizin (33%) followed by benzodiazepine related drugs (zopiclone and zolpidem; 20%), propiomazine (14%) and benzodiazepines (13%). The majority (68%) of the prescriptions were from primary care. Most new users were prescribed 1\u201330DDDs and 52% among women and 49% among men were dispensed their drug only once during the first year. Half of the new users had a previous comorbid psychiatric disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The findings are well reflecting the recommendations in national guidelines.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mpr.1998","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T06:11:00Z","timestamp":1707891060000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["New users of anxiolytics and sedatives in Sweden\u2014Drug type, doses, prescribers' characteristics, and psychiatric comorbidity in more than 750,000 patients"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5502-2405","authenticated-orcid":false,"given":"Elin","family":"Dahl\u00e9n","sequence":"first","affiliation":[{"name":"The Swedish Medical Products Agency  Uppsala Sweden"},{"name":"Department of Clinical Science and Education S\u00f6dersjukhuset Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carola","family":"Bardage","sequence":"additional","affiliation":[{"name":"The Swedish Medical Products Agency  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulina","family":"Tuvendal","sequence":"additional","affiliation":[{"name":"The Swedish Medical Products Agency  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rickard","family":"Ljung","sequence":"additional","affiliation":[{"name":"The Swedish Medical Products Agency  Uppsala Sweden"},{"name":"Unit of Epidemiology Institute of Environmental Medicine Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4123"},{"key":"e_1_2_9_3_1","unstructured":"European Monitoring Centre for Drugs and Drug Addiction. (2021).New benzodiazepines in Europe\u2014a review. Accessed November 2022."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3825"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.12315"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787\u2010020\u201001598\u20101"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228\u2010011\u20101124\u20102"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4551"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.4088\/jcp.10m06176blu"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010016\u20100117\u2010y"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102458\u201011\u2010450"},{"key":"e_1_2_9_12_1","unstructured":"OECD stat\u2010pharmaceutical market. [Internet]. Available online:https:\/\/stats.oecd.org2022."},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406\u2010018\u20100966\u20103"},{"key":"e_1_2_9_14_1","volume-title":"R: A language and environment for statistical computing","author":"R Core Team","year":"2020"},{"key":"e_1_2_9_15_1","unstructured":"Statistics Sweden. (2022).Population statistics. [Internet]. Retrieved fromhttps:\/\/www.statistikdatabasen.scb.se\/pxweb\/sv\/ssd\/START__BE__BE0101__BE0101A\/BefolkningR1860N\/"},{"key":"e_1_2_9_16_1","unstructured":"Swedish translation of the international classification of diseases 10th revision (ICD\u201010\u2010SE) World health organization. [Internet]. Available from:https:\/\/www.socialstyrelsen.se\/statistik\u2010och\u2010data\/klassifikationer\u2010och\u2010koder\/icd\u201010\/"},{"key":"e_1_2_9_17_1","unstructured":"The National Board of Health and Welfare. (2021a).Nationella riktlinjer f\u00f6r v\u00e5rd vid depression och \u00e5ngest."},{"key":"e_1_2_9_18_1","unstructured":"The National Board of Health and Welfare. (2021b).Statistical database pharmaceuticals."},{"key":"e_1_2_9_19_1","unstructured":"The pharmaceutical Benefits Act (SFS 2002:160 5\u00a7)."},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1827"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12613"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1294"},{"key":"e_1_2_9_23_1","unstructured":"WHO Collaborating Center for Drug Statistics Methodology. (2021).Oslo. Guidelines for ATC classification and DDD assignment. [Accessed 2021 June]."},{"key":"e_1_2_9_24_1","unstructured":"WHO Collaborating Center for Drug Statistics Methodology. (2022).Oslo Guidelines for ATC classification and DDD assignment."},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2011.07.018"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1017\/s2045796021000275"}],"container-title":["International Journal of Methods in Psychiatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mpr.1998","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T15:23:53Z","timestamp":1711553033000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mpr.1998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,13]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/mpr.1998"],"URL":"https:\/\/doi.org\/10.1002\/mpr.1998","archive":["Portico"],"relation":{},"ISSN":["1049-8931","1557-0657"],"issn-type":[{"value":"1049-8931","type":"print"},{"value":"1557-0657","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,13]]},"assertion":[{"value":"2023-03-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1998"}}