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The association of a child's temperament and parental characteristics with the QoL of autistic children remains unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We constructed an autism module based on a thematic analysis, a Delphi survey with experts, and a pre\u2010test with parents to be completed alongside the proxy version of the PedsQL 4.0. We explored compliance, responsiveness, internal consistency, convergent validity, and factor structure with 157 parents of autistic preschool children. We examined the association between child and parental characteristics with the QoL of autistic children using correlation analysis, principal component analysis, hierarchical ascending classification, and linear regression. Sociodemographic information was collected via multiple choice questions, autism severity via Autism Diagnostic Observation Schedule (ADOS)\u00a0scores, and parental acceptance and child's temperament via the Acceptance and Action Questionnaire and the Emotionality, Activity, and Sociability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An autism module comprised of 27 items emerged. Psychometric evaluation resulted in a 24\u2010item autism module with good internal consistency and significant convergent validity. ADOS total score was not significantly related to QoL, contrary to children's sleep issues, children's emotionality, and parental acceptance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The autism module is a reliable QoL proxy measure for autistic preschool children. Results suggest parental interventions targeting children's QoL.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mpr.2002","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T15:19:40Z","timestamp":1703258380000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Development, psychometric evaluation, and factor analysis of an instrument measuring quality of life in autistic preschoolers"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5147-559X","authenticated-orcid":false,"given":"J\u00e9r\u00f4me","family":"Lichtl\u00e9","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 Laboratoire de Psychopathologie et Processus de Sant\u00e9  Boulogne\u2010Billancourt France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3987-1842","authenticated-orcid":false,"given":"Emmanuel","family":"Devouche","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 Laboratoire de Psychopathologie et Processus de Sant\u00e9  Boulogne\u2010Billancourt France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaora Zefania","family":"Dialahy","sequence":"additional","affiliation":[{"name":"Centre Int\u00e9gr\u00e9 Universitaire de Sant\u00e9 et des Services Sociaux du Nord de l\u2019\u00eele de Montr\u00e9al  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aude","family":"de Gaulmyn","sequence":"additional","affiliation":[{"name":"Centre de Recherche et Diagnostic pour l'Autisme et Troubles Apparent\u00e9s (CREDAT, H\u00f4pital Sainte\u2010Anne GHU Paris Psychiatrie &amp; Neurosciences)  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anouck","family":"Amestoy","sequence":"additional","affiliation":[{"name":"INCIA, UMR 5287 CNRS Bordeaux Neurocampus. 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