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Besides its scientific relevance, this knowledge may contribute to improve selective and indicated prevention, early detection, treatment and cannabis policies. The secondary objectives are the identification of factors related to treatment seeking and the validation of self report measures of cannabis use.<\/jats:p><jats:p>Between September 2008 and April 2009, baseline data were collected from 600 frequent cannabis users with an average age of 22.1\u2009years, predominantly male (79.3%) and an average cannabis use history of 7.1\u2009years; 42.0% fulfilled a (12\u2010month DSM\u2010IV) diagnosis of cannabis dependence. The response rate was 83.7% after the first follow up at 18\u2009months. The second and last follow\u2010up is planned at 36\u2009months. Computer assisted personal interviews (CAPI) were conducted which covered: cannabis use (including detailed assessments of exposure, motives for use and potency preference); use of other substances; DSM\u2010IV internalizing and externalizing mental disorders; treatment seeking; personality; life events; social support and social functioning. 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