{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:50:18Z","timestamp":1791352218236,"version":"4.3.1"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Methods Psych Res"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Smoking has been linked to both peripheral ghrelin levels and depressive symptoms. However, the association between cerebrospinal fluid (CSF) ghrelin levels and depressive symptoms, and the moderating role of smoking, remains unclear. This study aims to investigate the specific relationship among the three categories.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this case\u2010control study, we examined the association between smoking, depressive symptoms, and CSF ghrelin levels in 173 adult male volunteers (94 non\u2010smokers and 79 active smokers). Demographic data, clinical parameters, and Beck Depression Inventory (BDI\u2010SF) scores were assessed, and CSF ghrelin levels were measured. Statistical analyses, including the Mann\u2010Whitney rank\u2010sum test, Spearman correlation, and linear regression, were used to explore the relationships among these variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Active smokers had significantly higher BDI scores (3.57\u00a0\u00b1\u00a04.74 vs. 1.44\u00a0\u00b1\u00a02.33,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and lower CSF ghrelin levels (1201.99\u00a0\u00b1\u00a0145.97 vs. 1563.61\u00a0\u00b1\u00a0153.3,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) compared with non\u2010smokers. Correlation analysis revealed a significant negative association between CSF ghrelin levels and BDI scores (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u22120.197,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01). Smoking was positively correlated with BDI scores (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.332,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and negatively correlated with CSF ghrelin levels (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u22120.780,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Moderation analysis further indicated that smoking significantly moderated the association between CSF ghrelin levels and depressive symptoms (Smoking \u00d7 CSF ghrelin:\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.047).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CSF ghrelin levels are associated with depressive symptoms. A significant negative correlation exists between CSF ghrelin levels and smoking, and smoking appears to moderate the association between CSF ghrelin and depressive symptoms. These findings provide potential insights into the pre\u2010clinical mechanisms of depression and early prevention strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mpr.70108","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:55:26Z","timestamp":1791348926000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Cerebrospinal Fluid Ghrelin Levels and Depressive Symptoms is Moderated by Smoking: A Case\u2010Control Study"],"prefix":"10.1002","volume":"35","author":[{"given":"Yueling","family":"Hu","sequence":"first","affiliation":[{"name":"Disease Control and Prevention Center of Jinniu District  Chengdu City Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Mental Health Wenzhou Medical University  Wenzhou 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