{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:01:40Z","timestamp":1761487300443,"version":"build-2065373602"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,1,27]],"date-time":"2005-01-27T00:00:00Z","timestamp":1106784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Asturpharma SA."},{"DOI":"10.13039\/501100008430","name":"Consejer\u00eda de Educaci\u00f3n y Cultura del Principado de Asturias (FICYT)","doi-asserted-by":"crossref","award":["PC-CIS01-22","PR-01-GE-9."],"award-info":[{"award-number":["PC-CIS01-22","PR-01-GE-9."]}],"id":[{"id":"10.13039\/501100008430","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Reson in Chemistry"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>New spiro\u2010piperidylrifamycin derivatives are presented. These compounds were synthesized from the reaction of 3\u2010amino\u20104\u2010iminorifamycin S and enantiomerically pure 4\u2010piperidones, which generate diasteroisomeric rifabutin analogues with a new stereocentre at the spiranic carbon. The <jats:sup>1<\/jats:sup>H and <jats:sup>13<\/jats:sup>C NMR spectra of these new compounds, and also the configuration of the new stereogenic centres, were assigned using 2D NMR spectroscopic techniques. A preliminary study of the <jats:sup>1<\/jats:sup>H and <jats:sup>13<\/jats:sup>C NMR spectra of the starting compounds rifamycin S, 3\u2010amino\u20104\u2010iminorifamycin S and the related rifabutin was also carried out and as a result, their previously published <jats:sup>13<\/jats:sup>C NMR data were corrected. 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