{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T18:35:36Z","timestamp":1778697336678,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T00:00:00Z","timestamp":1353369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Reson in Chemistry"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p><jats:italic>N<\/jats:italic><jats:sub>2<\/jats:sub>\u2010Isobutyrylguanine was prepared by treatment of guanine with isobutyryl chloride. Two tautomers, 1,7\u2010dihydro\u20102\u2010(isobutyroyl)amino\u20106<jats:italic>H<\/jats:italic>\u2010purin\u20106\u2010one and 1,9\u2010dihydro\u20102\u2010(isobutyroyl)amino\u20106<jats:italic>H<\/jats:italic>\u2010purin\u20106\u2010one, were identified in almost 1\u2009:\u20091 ratio in dichloromethane\u2013dimethyl sulfoxide (1\u2009:\u20091\u2009v\/v) by NMR spectroscopy. By using the selective\u2010inversion experiments, enthalpy, entropy, and free energy for activation were determined. This work represents the first report of guanine tautomers observed directly by NMR spectroscopy. 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