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NMR is well suited for interrogating transient intermediates, providing kinetic information via NMR active nuclei, and most importantly provides universally quantitative information for all species in solution. This contrasts with commonly used PAT instruments, such as Raman or Flow\u2010infrared (IR), which requires a separate calibration curve for every component of the reaction mixture. To date, the large footprint of high\u2010field (\u2265400 MHz) NMR spectrometers and the immobility of superconducting magnets, coupled with strict requirements for the architecture for the room it is to be installed, have been a major obstacle to using this technology right next to fume hoods where chemists perform synthetic work. Here, we describe the use of a small, lightweight 60 MHz Benchtop NMR system (Nanalysis Pro\u201060) located on a mobile platform, that was used to monitor both small and intermediate scale Grignard formation and coupling reactions. We also show how low field NMR can provide a deceptively simple yes\/no answer (for a system that would otherwise require laborious off\u2010line testing) in the enrichment of one component <jats:italic>versus<\/jats:italic> another in a kilogram scale distillation. Benchtop NMR was also used to derive molecule specific information from Flow\u2010IR, a technology found in most manufacturing sites, and compare the ease at which the concentrations of the reaction mixtures can be derived by NMR versus IR.<\/jats:p>","DOI":"10.1002\/mrc.5035","type":"journal-article","created":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T09:44:38Z","timestamp":1588585478000},"page":"1193-1202","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["NMR spectroscopy goes mobile: Using NMR as process analytical technology at the fume hood"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4995-4791","authenticated-orcid":false,"given":"William G.","family":"Lee","sequence":"first","affiliation":[{"name":"NorthEastern University  Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark T.","family":"Zell","sequence":"additional","affiliation":[{"name":"Takeda Pharmaceuticals  Cambridge MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Ouchi","sequence":"additional","affiliation":[{"name":"Takeda Pharmaceuticals  Cambridge MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4086-6699","authenticated-orcid":false,"given":"Mark J.","family":"Milton","sequence":"additional","affiliation":[{"name":"Takeda Pharmaceuticals  Cambridge MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,9]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Guidance for Industry Q8(R2) Pharmaceutical Development","author":"F. 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