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Several recently reported peak assignments in the solid\u2010state <jats:sup>13<\/jats:sup>C NMR spectrum of HPMCAS have been corrected here using peak integrals in quantitative spectra, spectral editing, empirical chemical\u2010shift predictions based on solution NMR, and full spectrum simulation analogous to deconvolution. Unlike in cellulose, the strong peak at 84\u2009ppm must be assigned to C2 and C3 methyl ethers, instead of regular C4 of cellulose. The proposed assignment of signals at &lt;65\u2009ppm to OCH sites, including C5 of cellulose, could not be confirmed. CH<jats:sub>2<\/jats:sub> spectral editing showed two resolved OCH<jats:sub>2<\/jats:sub> bands, a more intense one from O\u2010CH<jats:sub>2<\/jats:sub> ethers of C6 at &gt;69\u2009ppm and a smaller one from its esters and possibly residual CH<jats:sub>2<\/jats:sub>\u2010OH groups, near 63\u2009ppm. The strong intensities of resolved signals of acetyl, succinoyl, and oxypropyl substituents indicated the substitution of &gt;85% of the OH groups in HPMCAS. The side\u2010group concentrations in three different grades of HPMCAS were quantified.<\/jats:p>","DOI":"10.1002\/mrc.5390","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T00:25:06Z","timestamp":1693441506000},"page":"595-605","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Corrected solid\u2010state <sup>13<\/sup>C nuclear magnetic resonance peak assignment and side\u2010group quantification of hydroxypropyl methylcellulose acetyl succinate pharmaceutical excipients"],"prefix":"10.1002","volume":"61","author":[{"given":"Zhaoxi","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Chemistry Brandeis University  Waltham Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5063-3218","authenticated-orcid":false,"given":"Yongchao","family":"Su","sequence":"additional","affiliation":[{"name":"Analytical Research and Development Merck &amp; Co., Inc.  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