{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T07:06:38Z","timestamp":1776409598975,"version":"3.51.2"},"reference-count":61,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100019184","name":"Centro de Investiga\u00e7\u00e3o em Biomedicina","doi-asserted-by":"publisher","award":["CBMR\/IMR\/0008\/2021"],"award-info":[{"award-number":["CBMR\/IMR\/0008\/2021"]}],"id":[{"id":"10.13039\/501100019184","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001849","name":"Defence Research and Development Organisation","doi-asserted-by":"publisher","award":["LSRB\/01\/15001\/LSRB\u2010404\/PEE&BS\/2023"],"award-info":[{"award-number":["LSRB\/01\/15001\/LSRB\u2010404\/PEE&BS\/2023"]}],"id":[{"id":"10.13039\/501100001849","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Reson in Chemistry"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Acute respiratory distress syndrome (ARDS) is a life\u2010threatening condition often complicated by sepsis, leading to worse clinical outcomes. The role of biomarkers in distinguishing ARDS with and without sepsis remains unclear. This study aimed to evaluate the differences in serum metabolites between the two groups, comparing levels on Day 1 and Day 7 of intensive care unit (ICU) admission, and to assess the variation in outcomes via clinical characteristics. A cohort of\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009151 patients was included, with\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200991 providing serum samples on Day 1 and\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200960 on Day 7. Of the\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200991 patients on Day 1,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200940 had ARDS with sepsis and\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200951 without sepsis, while on Day 7,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200924 had ARDS with sepsis and\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200936 without. Serum samples were analyzed using\n                    <jats:sup>1<\/jats:sup>\n                    H NMR\u2010based metabolomics to identify altered metabolites and perturbed pathways. In contrast, no significant differences were found between the patient groups with and without sepsis on either Day 1 or Day 7. Mortality rates were also similar in both groups, with a 50% survival rate on Day 7. No notable differences in the clinical data were observed. These findings suggest that ARDS, with and without sepsis, exhibits a similar metabolic profile, likely due to shared pathophysiological mechanisms. In light of these similarities, the findings indicate a unified approach to ARDS management that may improve the clinical outcomes across both groups.\n                  <\/jats:p>","DOI":"10.1002\/mrc.70032","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T09:16:25Z","timestamp":1756977385000},"page":"1035-1049","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Longitudinal NMR\u2010Based Metabolomics Highlights Shared Mechanisms of Pathophysiology in ARDS Patients With and Without Sepsis"],"prefix":"10.1002","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0743-7575","authenticated-orcid":false,"given":"Anamika","family":"Singh","sequence":"first","affiliation":[{"name":"Centre of Biomedical Research SGPGIMS Campus  Lucknow India"},{"name":"Academy of Scientific and Innovative Research  Ghaziabad Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3677-5791","authenticated-orcid":false,"given":"Mohd\u00a0Adnan","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Centre of Biomedical Research SGPGIMS Campus  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3077-5424","authenticated-orcid":false,"given":"Afzal","family":"Azim","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Sanjay Gandhi Postgraduate Institute of Medical Sciences  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3235-6127","authenticated-orcid":false,"given":"Neeraj","family":"Sinha","sequence":"additional","affiliation":[{"name":"Centre of Biomedical Research SGPGIMS Campus  Lucknow India"},{"name":"Academy of Scientific and Innovative Research  Ghaziabad Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-5231(21)00140-4"},{"issue":"3","key":"e_1_2_11_3_1","first-page":"513","article-title":"Delayed Treatment Contributes to Mortality in ICU Patients With Severe Active Pulmonary Tuberculosis and Acute Respiratory Failure","volume":"27","author":"Zahar J. 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