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While crystal engineering has provided key principles for designing cocrystals, detailed experimental insights into the specific intermolecular interactions governing cocrystallization remain important for structurally complex APIs. We investigate the cocrystallization of an antileukemia drug, venetoclax, with fumaric acid as a coformer. The formation of a new cocrystalline phase is confirmed through powder X\u2010ray diffraction (PXRD) and differential scanning calorimetry (DSC). Solid\u2010state nuclear magnetic resonance (NMR) spectroscopy provides key insights into the cocrystallization mechanism, revealing specific hydrogen\u2010bonding interactions between the aromatic amine and pyrrole groups of venetoclax and the carboxylic groups of fumaric acid. These results not only demonstrate a successful case of cocrystallization but also highlight the value of complementary solid\u2010state characterization techniques, PXRD, DSC, and solid\u2010state NMR, in probing cocrystal formation and elucidating the underlying supramolecular interactions in complex pharmaceutical systems.<\/jats:p>","DOI":"10.1002\/mrc.70039","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T08:01:07Z","timestamp":1758873667000},"page":"26-33","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Solid\u2010State NMR Elucidation of Intermolecular Interactions in Venetoclax\u2013Fumaric Acid Cocrystal"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4454-2357","authenticated-orcid":false,"given":"Shovik","family":"Ray","sequence":"first","affiliation":[{"name":"Solid State and Structural Chemistry Unit Indian Institute of 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