{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T15:26:45Z","timestamp":1788276405644,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T00:00:00Z","timestamp":1781395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T00:00:00Z","timestamp":1781395200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2024\u2010BSBA\u201032"],"award-info":[{"award-number":["2024\u2010BSBA\u201032"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Reson in Chemistry"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Isodon rubescens<\/jats:italic>\n                    is a widely used traditional folk medicine in China. In this study, 13 natural products were isolated using a two\u2010step ethanol extraction. Notably, flavonoid glycosides\n                    <jats:bold>2<\/jats:bold>\n                    and\n                    <jats:bold>4<\/jats:bold>\n                    , and polymeric caffeic acids\n                    <jats:bold>7<\/jats:bold>\n                    and\n                    <jats:bold>8<\/jats:bold>\n                    , were identified for the first time from the secondary extraction residues, highlighting the continued presence of bioactive compounds with potential for further development. Oridonin (\n                    <jats:bold>9<\/jats:bold>\n                    ), the major active compound, was quantified in nine commercial preparations using quantitative NMR (qNMR). Its concentration in the drop pill (0.92\u2009mg\/g) was comparable to that in the raw extract (0.90\u2009mg\/g). The three tablet samples showed varying levels: Tablet 3 (2.66\u2009mg\/g)\u2009&gt;\u2009Tablet 1 (1.22\u2009mg\/g)\u2009&gt;\u2009Tablet 2 (1.09\u2009mg\/g). Capsule, tea bag, and syrup samples could not be quantified due to low concentrations.\n                  <\/jats:p>","DOI":"10.1002\/mrc.70123","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T04:57:05Z","timestamp":1781499425000},"page":"840-849","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Qualitative and Quantitative Characterization of\n                    <i>Isodon rubescens<\/i>\n                    and Its Pharmaceutical Preparations Using NMR and UHPLC\u2010QTOF\u2010MS"],"prefix":"10.1002","volume":"64","author":[{"given":"Qiong","family":"Wu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Marine Food Processing and Safety Control, National Engineering Research Center of Seafood, School of Food Science and Technology Dalian Polytechnic University  Dalian Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2363-4535","authenticated-orcid":false,"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Phytochemistry and Natural Medicines, Dalian Institute of Chemical Physics Chinese Academy of Sciences  Dalian Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yuan","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Key Laboratory for Pharmacodynamic Material Basis of Traditional Chinese Medicine Ganjiang Chinese Medicine Innovation Center  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Phytochemistry and Natural Medicines, Dalian Institute of Chemical Physics Chinese Academy of Sciences  Dalian Liaoning China"},{"name":"Jiangxi Provincial Key Laboratory for Pharmacodynamic Material Basis of Traditional Chinese Medicine Ganjiang Chinese Medicine Innovation Center  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfang","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Phytochemistry and Natural Medicines, Dalian Institute of Chemical Physics Chinese Academy of Sciences  Dalian Liaoning China"},{"name":"Jiangxi Provincial Key Laboratory for Pharmacodynamic Material Basis of Traditional Chinese Medicine Ganjiang Chinese Medicine Innovation Center  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,14]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Pharmacopoeia of the People's Republic of China","author":"China Pharmacopoeia Committee","year":"2020"},{"key":"e_1_2_9_3_1","first-page":"2","article-title":"Study on Modern Pharmacological and Chemical Components and Clinical Medication of Isodon rubescens (Chinese)","volume":"33","author":"Xiong H.","year":"2014","journal-title":"Inner Mongolia Traditional Chinese Medicine"},{"issue":"19","key":"e_1_2_9_4_1","first-page":"6543","article-title":"Textual Research, Chemical Composition, Pharmacological Effects and Clinical Applications of Rabdosia rubescens (Chinese)","volume":"54","author":"Gao S. 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