{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:01:44Z","timestamp":1791136904376,"version":"4.1.0"},"reference-count":70,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,8,25]],"date-time":"2003-08-25T00:00:00Z","timestamp":1061769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Reproduction Devel"],"published-print":{"date-parts":[[2003,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Csnk2a2<\/jats:italic> encodes the CK2\u03b1\u2032catalytic subunit of CK2 that is predominantly expressed in testis. Male mice in which <jats:italic>Csnk2a2<\/jats:italic> has been disrupted were infertile and displayed oligozoospermia with an abnormal shape of the spermatid nucleus. In this study, <jats:italic>Csnk2a2<\/jats:italic> null testes revealed extensive germ cell degenerative processes at all stages of spermatogenesis, including the first spermatogenesis wave. Nuclear envelope (NE) protrusions with loss of nuclear pores, swelling of the outer membrane, and disruption of the inner membrane were observed in cells ranging from spermatogonia to early spermatids. Most early round spermatids were depleted, and DNA\u2010specific fluorescent dyes showed a large chromatin\u2010free nuclear domain near the chromocenter. Spermatids that were not eliminated retained NE defects that could explain the acrosomal and nuclear abnormalities of <jats:italic>Csnk2a2<\/jats:italic> null spermatozoa. Data suggest that CK2\u03b1\u2032 deficiency could impair the phosphorylation of nuclear proteins of male germ cells leading to a particular cell\u2010death pathway characterized by NE protrusions and an unusual pattern of chromatin modifications in spermatids. Mol. Reprod. Dev. 66: 190\u2013201, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mrd.10346","type":"journal-article","created":{"date-parts":[[2003,8,26]],"date-time":"2003-08-26T15:26:25Z","timestamp":1061911585000},"page":"190-201","source":"Crossref","is-referenced-by-count":79,"title":["Spermatogenesis of mice lacking CK2\u03b1\u2032: Failure of germ cell survival and characteristic modifications of the spermatid 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