{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:45:52Z","timestamp":1791251152954,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2003,9,12]],"date-time":"2003-09-12T00:00:00Z","timestamp":1063324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Reproduction Devel"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to examine the expression and regulation of peroxisome proliferator\u2010activated receptor (PPAR) <jats:italic>PPAR\u03b4<\/jats:italic> gene in mouse uterus during early pregnancy by in situ hybridization and immunohistochemistry. PPAR\u03b4 expression under pseudopregnancy, delayed implantation, hormonal treatment, and artificial decidualization was also investigated. There was a very low level of PPAR\u03b4 expression on days 1\u20134 of pregnancy. On day 5 when embryo implanted, PPAR\u03b4 expression was exclusively observed in the subluminal stroma surrounding the implanting blastocyst. No corresponding signals were seen in the uterus on day 5 of pregnancy. There was no detectable PPAR\u03b4 signal under delayed implantation. Once delayed implantation was terminated by estrogen treatment and embryo implanted, a strong level of PPAR\u03b4 expression was induced in the subluminal stroma surrounding the implanting blastocyst. Estrogen treatment induced a moderate level of PPAR\u03b4 expression in the glandular epithelium, while progesterone treatment had no effects in the ovariectomized mice. A strong level of PPAR\u03b4 expression was seen in the decidua on days 6\u20138 of pregnancy. PPAR\u03b4 expression was also induced under artificial decidualization. These data suggest that PPAR\u03b4 expression at implantation sites require the presence of an active blastocyst and may play an essential role for blastocyst implantation. Mol. Reprod. Dev. 66: 218\u2013224, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mrd.10348","type":"journal-article","created":{"date-parts":[[2003,9,16]],"date-time":"2003-09-16T13:36:12Z","timestamp":1063719372000},"page":"218-224","source":"Crossref","is-referenced-by-count":44,"title":["Peroxisome proliferator\u2010activated receptor delta expression and regulation in mouse uterus during embryo implantation and decidualization"],"prefix":"10.1002","volume":"66","author":[{"given":"Nai\u2010Zheng","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Bo","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing\u2010Hong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Bin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeng\u2010Ming","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,9,12]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80209-9"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.012610299"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1677\/jme.0.0160107"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.20.5.649"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.00766.x"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.24.13275"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.15.6.3012"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.138.11.4599"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80402-X"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.12.1561"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.11.8126"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(98)00214-7"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M203997200"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.1.99"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod67.1.351"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1986.tb20920.x"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(99)00033-7"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(96)00066-5"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.052707099"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/359076a0"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(97)01481-6"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2795(199604)43:4<470::AID-MRD9>3.0.CO;2-M"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0120593"}],"container-title":["Molecular Reproduction and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmrd.10348","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrd.10348","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T16:13:50Z","timestamp":1700237630000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrd.10348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,9,12]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,11]]}},"alternative-id":["10.1002\/mrd.10348"],"URL":"https:\/\/doi.org\/10.1002\/mrd.10348","archive":["Portico"],"relation":{},"ISSN":["1040-452X","1098-2795"],"issn-type":[{"value":"1040-452X","type":"print"},{"value":"1098-2795","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,9,12]]}}}