{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:15:05Z","timestamp":1791065705133,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,2,4]],"date-time":"2005-02-04T00:00:00Z","timestamp":1107475200000},"content-version":"vor","delay-in-days":5482,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Reproduction Devel"],"published-print":{"date-parts":[[1990,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The multidrug resistance (<jats:italic>mdr<\/jats:italic>) gene family has been shown to encode a membrane glycoprotein, termed the P\u2010glycoprotein, which functions as a drug efflux pump with broad substrate specificity. This multigene family is expressed in a tissue\u2010specific fashion in a wide variety of normal and neoplastic tissues. The regulation of <jats:italic>mdr<\/jats:italic> gene expression in normal tissues is not understood. We have recently shown that <jats:italic>mdr<\/jats:italic> mRNA and the P\u2010glycoprotein increases dramatically in the secretory luminal and glandular epithelium of the gravid murine uterus. This observation has suggested that <jats:italic>mdr<\/jats:italic> gene expression in the uterus is controlled by the physiologic changes associated with pregnancy. This report now demonstrates that <jats:italic>mdr<\/jats:italic> mRNA and P\u2010glycoprotein are induced at high levels in the uterine secretory epithelium by the combination of estrogen and progesterone, the major steroid hormones of pregnancy. This regulation of <jats:italic>mdr<\/jats:italic> gene expression in the uterus does not require any other contribution from the fetus or placenta. The data indicate that this gene locus is hormonally responsive to estrogen and progesterone in the uterine secretory epithelium, suggesting an important and physiologically regulated role during pregnancy.<\/jats:p>","DOI":"10.1002\/mrd.1080250202","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T00:35:51Z","timestamp":1109205351000},"page":"101-109","source":"Crossref","is-referenced-by-count":89,"title":["Multidrug resistance gene expression is controlled by steroid hormones in the secretory epithelium of the uterus"],"prefix":"10.1002","volume":"25","author":[{"given":"Robert J.","family":"Arceci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Baas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romeo","family":"Raponi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan Band","family":"Horwitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Housman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Croop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,2,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90585-4"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.12.4350"},{"key":"e_1_2_1_4_1","first-page":"81","volume-title":"Implantation of the Ovum","author":"Beier HM","year":"1976"},{"key":"e_1_2_1_5_1","first-page":"264","volume-title":"21 Coll. 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