{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:05:50Z","timestamp":1761717950974},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,2,4]],"date-time":"2005-02-04T00:00:00Z","timestamp":1107475200000},"content-version":"vor","delay-in-days":4997,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Reproduction Devel"],"published-print":{"date-parts":[[1991,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To decipher genes that are important in the determination of laterality, we compared two\u2010dimensional protein gels from wild\u2010type C57BL\/6J mice and C57BL\/6J mice that carried the <jats:italic>iv<\/jats:italic> mutation, which confers random determination of visceral situs. To span the time period(s) during which laterality determination occurs, we compared computer\u2010analyzed two\u2010dimensional protein gels from wild\u2010type mouse embryos and <jats:italic>iv\/iv<\/jats:italic> mouse embryos at 7.5, 8.0, and 8.5 days post\u2010coitum. One polypeptide that was expressed only on day 8.0 of development and only in wild\u2010type embryos represents a particular candidate for determination of laterality. Day 8.5 postcoitum represents the earliest time in murine development that laterality is manifest. Two\u2010dimensional gels were compared from 8.5 day embryos that were C57BL\/6J wild\u2010type, C57BL\/6J <jats:italic>iv\/iv<\/jats:italic>, or C57BL\/6J wild\u2010type and exposed to the teratogen retinoic acid late on day 7. Reproducible alterations of protein synthesis were observed in both the <jats:italic>iv<\/jats:italic> genocopy and retinoic acid phenocopy, yielding abnormal laterality determination. The intersection of these peptide changes identifies a protein likely to play a role in the determination of laterality.<\/jats:p>","DOI":"10.1002\/mrd.1080290208","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T00:42:36Z","timestamp":1109205756000},"page":"136-144","source":"Crossref","is-referenced-by-count":14,"title":["Situs inversus in the developing mouse: Proteins affected by the <i>iv<\/i> mutation (genocopy) and the teratogen retinoic acid (phenocopy)"],"prefix":"10.1002","volume":"29","author":[{"given":"Margaret L.","family":"Van Keuren","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William M.","family":"Layton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruxandra A.","family":"Iacob","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David 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