{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:51:20Z","timestamp":1789195880956,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,2,4]],"date-time":"2005-02-04T00:00:00Z","timestamp":1107475200000},"content-version":"vor","delay-in-days":4875,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Reproduction Devel"],"published-print":{"date-parts":[[1991,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adult XYSxr<jats:sup>a<\/jats:sup> mice exhibit varying degrees of spermatogenic deficiency but are usually fertile, while XOSxr<jats:sup>a<\/jats:sup> mice have severe spermatogenic failure and are always sterile. The present quantitative spermatogenic analysis documents when these anomalies first appear during puberty. The results demonstrate that in XYSxr<jats:sup>a<\/jats:sup> mice there was increased degeneration of pachytene spermatocytes and, to a lesser extent, meiotic metaphase stages. On average, there were only one\u2010half the number of spermatids compared with the XY controls. The defect in XOSxr<jats:sup>a<\/jats:sup> mice appeared a little later, with an almost complete arrest and degeneration during the meiotic metaphases, so that the number of spermatids produced was only 3% of the control value. These results are discussed in relation to an hypothesis that links sex chromosome univalence during meiotic prophase with spermatogenic failure.<\/jats:p>","DOI":"10.1002\/mrd.1080300202","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T00:19:39Z","timestamp":1109204379000},"page":"81-89","source":"Crossref","is-referenced-by-count":39,"title":["Spermatogenesis in XY, XYSxr<sup>a<\/sup> and XOSxr<sup>a<\/sup> mice: A quantitative analysis of spermatogenesis throughout puberty"],"prefix":"10.1002","volume":"30","author":[{"given":"Maxine J.","family":"Sutcliffe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Darling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Burgoyne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,2,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00274192"},{"key":"e_1_2_1_3_1","first-page":"349","volume-title":"Controlling Events in Meiosis (38th Symp Soc Exp Biol)","author":"Burgoyne PS","year":"1984"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0680381"},{"key":"e_1_2_1_5_1","unstructured":"BurgoynePS MahadevaiahSK SutcliffeMJ PalmerSJ(1991): Sterility in XOSxramice is due to the lack of X\u2010Y pairing and to the lack of a Y\u2010chromosomal sperm morphology gene. 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