{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T17:45:14Z","timestamp":1759599914552},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,2,4]],"date-time":"2005-02-04T00:00:00Z","timestamp":1107475200000},"content-version":"vor","delay-in-days":4539,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Reproduction Devel"],"published-print":{"date-parts":[[1992,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The glycoprotein hormone human chorionic gonadotropin (hCG) is synthesized in large quantities by the developing placenta, reaching peak concentrations in maternal blood during the late first trimester and early midtrimester of pregnancey. In general it is believed that the \u03b2\u2010subunit of this dimeric hormone is expressed in pituitary gonadotropes, thyrotropes, and trophoblasts, while the \u03b2\u2010subunit is expressed exclusively by trophoblasts. Studies from our laboratory and other laboratories have shown that some midtrimester human fetal tissues, in addition to the placenta, can synthesize proteins that appear to be very similar to the \u03b2\u2010subunit of hCG. To define precisely the nature of this putative hCG\u2010\u03b2\u2010subunit in extraplacental fetal tissues, we have examined the mRNA from a variety of human fetal and adult tissues using nucleic acid hybridization and reverse transcription\u2010polymerase chain reaction (PCR) methods. Our results demonstrate that midtrimester fetal kidney and adrenal tissues contain hCG\u2010\u03b2 mRNA transcripts at concentrations comparable to that of placenta, while fetal lung, brain, muscle, and adult adrenal contain only trace to undetectable levels of hCG\u2010\u03b2 mRNA. By restriction endonuclease mapping of PCR fragments from fetal tissue cDNAs, we show that the hCG\u2010\u03b2 transcript expressed in midtrimester human fetal organs is a bone fide copy of hCG\u2010\u03b2 gene No. 5 of the \u03b2\u2010subunit gene family located on chromosome 19. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mrd.1080330102","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T00:07:13Z","timestamp":1109203633000},"page":"1-6","source":"Crossref","is-referenced-by-count":9,"title":["Extraplacental human fetal tissues express mRNA transcripts encoding the human chrorionic gonadotropin\u2010\u03b2 subunit protein"],"prefix":"10.1002","volume":"33","author":[{"given":"Paula A.","family":"Rothman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor 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