{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T09:10:54Z","timestamp":1698397854556},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,2,4]],"date-time":"2005-02-04T00:00:00Z","timestamp":1107475200000},"content-version":"vor","delay-in-days":3353,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Reproduction Devel"],"published-print":{"date-parts":[[1995,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In mice, expression of the transcription factor Oct\u20103 and the proto\u2010oncogene <jats:italic>c\u2010mos<\/jats:italic> is limited to germ cells, suggesting a specific role for these factors in gamete physiology and early embryonic development. We have studied the expression pattern of Oct\u20103 and <jats:italic>c\u2010mos<\/jats:italic> in various reproductive as well as control tissues in the cynomolgus monkey, using reverse transcriptase polymerase chain reaction (RT\u2010PCR) and Northern analysis. Analogously with the data from the mouse model, strong expression of Oct\u20103 and <jats:italic>c\u2010mos<\/jats:italic> could be detected in monkey ovary and oocytes. Unexpectedly, strong expression of <jats:italic>c\u2010mos<\/jats:italic> was demonstrable in the pituitary gland and the amount of mRNA expression in the pituitary was roughly equal to that found in the ovary. Of the tissues examined, the testicular expression of <jats:italic>c\u2010mos<\/jats:italic> was the most intense. Weak signal for <jats:italic>c\u2010mos<\/jats:italic> mRNA was also seen in hypothalamus and brain; however, all other tissue types examined were negative for <jats:italic>c\u2010mos<\/jats:italic> expression. In addition to the oocytes, expression of Oct\u20103 mRNA was detected in the ovarian granulosa cells, fallopian tube, myometrium, cervix, breast, liver, adrenal gland, pituitary, hypothalamus, brain cortex, prostate, and in testis. Thus, in the cynomolgus monkey, Oct\u20103 is predominantly, but not specifically, expressed in reproductive tissues. In the female monkey reproductive organs, the expression of <jats:italic>c\u2010mos<\/jats:italic> seems to be germ cell specific. Therefore, further characterization of <jats:italic>c\u2010mos<\/jats:italic> and Oct\u20103 functions in primate reproductive physiology, especially in gametogenesis and early embryonic development, is highly warranted. \u00a9 1995 wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mrd.1080420405","type":"journal-article","created":{"date-parts":[[2005,2,23]],"date-time":"2005-02-23T22:55:54Z","timestamp":1109199354000},"page":"397-406","source":"Crossref","is-referenced-by-count":4,"title":["Primate reproductive organs reveal a novel pattern of proto\u2010oncogene <i>c\u2010mos<\/i> and transcription factor Oct\u20103 mRNA expression"],"prefix":"10.1002","volume":"42","author":[{"given":"O.","family":"Heikinheimo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. W.","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. E.","family":"Lanzendorf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. P.","family":"Toner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. 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