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Quantitative measurements of this family of proteins were performed in men with low levels of serum testosterone (idiopathic hypogonadotropic hypogonadism) and in individuals having serum testosterone in the normal range of values but carrying sex chromosome aberrations (Klinefelter's syndrome). In the first case we have found a marked decrease in the total amount of the RSV\u2010IV\u2010related proteins. An increase of about 40% in the total amount of these antigens was obtained in these subjects by gonadotropin treatment. A decreased amount of these proteins was also detected in the subjects affected by Klinefelter's syndrome. The possibility that some factor(s) under genetic control is involved, in addition to testosterone, in the regulation of this family of proteins is discussed.<\/jats:p>","DOI":"10.1002\/mrd.1120160305","type":"journal-article","created":{"date-parts":[[2005,2,25]],"date-time":"2005-02-25T13:04:26Z","timestamp":1109336666000},"page":"229-241","source":"Crossref","is-referenced-by-count":21,"title":["A protein family immunorelated to a sperm\u2010binding protein and its regulation in human semen"],"prefix":"10.1002","volume":"16","author":[{"given":"S.","family":"Metafora","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Lombardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"De Rosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Quagliozzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Ravagnan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Peluso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Abrescia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/10.4.1159"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0730071"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-56-2-359"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1520\/JFS10729J"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1974.tb03599.x"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1093\/clinchem\/25.12.2051","article-title":"Immunological characterization of the creatine kinase isoenzyme in human semen","volume":"25","author":"Burgett MW","year":"1979","journal-title":"Clin Chem"},{"key":"e_1_2_1_8_1","first-page":"201","article-title":"Immunochemical studies of prostatic acid phosphatase","volume":"61","author":"Choe BK","year":"1977","journal-title":"Cancer Treat Rep"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0510073"},{"key":"e_1_2_1_10_1","first-page":"162","article-title":"Antigens from human seminal plasma. 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