{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:44:33Z","timestamp":1782513873702,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,2,17]],"date-time":"2005-02-17T00:00:00Z","timestamp":1108598400000},"content-version":"vor","delay-in-days":6441,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gamete Research"],"published-print":{"date-parts":[[1987,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study draws on decision analysis to estimate the utility of seminal variables in predicting pregnancy. The infertile couples selected (n = 709) excluded those who had donor insemination or known female factors (history of pelvic infection, ovulatory disorders, endometriosis, and tubal disease). Diagnostic test properties were calculated with respect to pregnancy for two variables derived from the semen analysis report: sperm density, and the total number of motile sperm in the ejaculate (TMS). Receiver\u2010operating characteristic (ROC) curves based on sensitivity and specificity revealed that none of the proposed thresholds for sperm density or TMS is clearly a best choice. The highest positive predictive values for sperm density (75%) and TMS (75%) were associated with cutoff points at five million sperm per milliliter and five million motile sperm per ejaculate, respectively. The false positive rates when these cutoff points were used were 4.3% (sperm density) and 5.6% (TMS). ROC analysis provides visual and numeric vidence of the quality of a diagnostic test and constitutes a set of procedures for incorporating information from new tests of male gamete function into the diagnostic assessment of infertility.<\/jats:p>","DOI":"10.1002\/mrd.1120170306","type":"journal-article","created":{"date-parts":[[2005,2,25]],"date-time":"2005-02-25T12:51:33Z","timestamp":1109335893000},"page":"229-236","source":"Crossref","is-referenced-by-count":9,"title":["Receiver\u2010operating characteristics curves for semen analysis variables: Methods for evaluating diagnostic tests of male gamete function"],"prefix":"10.1002","volume":"17","author":[{"given":"H\u2010Q.","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Collins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. H.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Wrixon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,2,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1439-0272.1983.tb00206.x","article-title":"Double blind cross over treatment with mesterolone and placebo of subfertile oligospermic men. Value of testicular biopsy","volume":"15","author":"Aafjes JH","year":"1983","journal-title":"Andrologia"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.1984.tb00792.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)44949-6"},{"key":"e_1_2_1_5_1","first-page":"9","volume-title":"Laboratory Manual for the Examination of Human Semen and Semen Cervical Mucus Interaction","author":"Belsey MA","year":"1980"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)47588-6"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.1982.tb00255.x"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.1984.tb00251.x"},{"key":"e_1_2_1_9_1","first-page":"31","article-title":"The clinical value of morphology rating of spermatozoa","volume":"30","author":"Bostofte E","year":"1985","journal-title":"Int J Fertil"},{"key":"e_1_2_1_10_1","first-page":"214","volume-title":"Clinical Biostatistics","author":"Feinstein AR","year":"1977"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016348409155526"},{"key":"e_1_2_1_12_1","first-page":"557","article-title":"Selection and interpretation of diagnostic test and procedures: Principles and applications","volume":"94","author":"Griner PF","year":"1981","journal-title":"Ann Int Med"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1986.tb09025.x"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/S0022-5347(17)74358-3","article-title":"The male factor in fertility and infertility'. II. Spermatozoan counts in 1000 men of known fertility and in 1000 cases of infertile marriage","volume":"66","author":"MacLeod J","year":"1951","journal-title":"J Urol"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM192905092001905"},{"key":"e_1_2_1_16_1","first-page":"163","article-title":"Evaluation of survival data and two new rank order statistics arising in its consideration","volume":"50","author":"Mantel N","year":"1966","journal-title":"Canc Chemother Rep"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-2998(78)80014-2"},{"key":"e_1_2_1_18_1","first-page":"66","volume-title":"Clinical Epidemiology: A Basic Science for Clinical Medicine","author":"Sackett DL","year":"1985"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0015-0282(16)38881-1","article-title":"Clinical investigation of the role of semen analysis and post coital tests in the evaluation of male infertility","volume":"23","author":"Santomauro AG","year":"1972","journal-title":"Fertil Steril"},{"key":"e_1_2_1_20_1","unstructured":"SmallDRJ CollinsJA WilsonEH WrixonW(1987): The interpretation of semen analysis among infertile couples.Canad Med Assoc J(in press)."},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(67)90005-0"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)42976-6"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.1120100210"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)42975-4"}],"container-title":["Gamete Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmrd.1120170306","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrd.1120170306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T07:49:20Z","timestamp":1697874560000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrd.1120170306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,7]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1987,7]]}},"alternative-id":["10.1002\/mrd.1120170306"],"URL":"https:\/\/doi.org\/10.1002\/mrd.1120170306","archive":["Portico"],"relation":{},"ISSN":["0148-7280","1554-3919"],"issn-type":[{"value":"0148-7280","type":"print"},{"value":"1554-3919","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,7]]}}}