{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T11:32:17Z","timestamp":1783078337527,"version":"3.54.6"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,4,21]],"date-time":"2004-04-21T00:00:00Z","timestamp":1082505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["HD 037394"],"award-info":[{"award-number":["HD 037394"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["HD36764"],"award-info":[{"award-number":["HD36764"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["AA12057"],"award-info":[{"award-number":["AA12057"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["HD98004"],"award-info":[{"award-number":["HD98004"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["HD37500"],"award-info":[{"award-number":["HD37500"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Perinatology Research Branch, Intramural Division, National Institute of Child Health and Human Development (National Institutes of Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Reproduction Devel"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Blastocyst implantation and placentation require molecular and cellular interactions between the uterine endometrium and blastocyst trophectoderm. Previous studies showed that histamine produced in the mouse uterine luminal epithelium interacts with trophoblast histamine type\u20102 receptors (H<jats:sub>2<\/jats:sub>) to initiate blastocyst implantation. However, it is unknown whether similar histamine activity is operative in humans. Using a human cell line (HTR\u20108\/SVneo) derived from first\u2010trimester cytotrophoblasts that expresses both histamine type\u20101 receptor (H<jats:sub>1<\/jats:sub>) and H<jats:sub>2<\/jats:sub>, we found that histamine promotes cytotrophoblast invasiveness specifically through activation of H<jats:sub>1<\/jats:sub>. Stimulation of H<jats:sub>1<\/jats:sub> in human cytotrophoblasts by histamine induced intracellular Ca<jats:sup>2+<\/jats:sup> (Ca<jats:sup>2+<\/jats:sup>i) transients by activating phospholipase C and the inositol trisphosphate pathway. The enhanced invasion induced by histamine was blocked by pretreatment with H<jats:sub>1<\/jats:sub> antagonist or by chelation of Ca<jats:sup>2+<\/jats:sup>i. These findings suggest possible differences between rodents and humans in histamine signaling to the trophoblast. Mol. Reprod. Dev. 68: 345\u2013353, 2004. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mrd.20082","type":"journal-article","created":{"date-parts":[[2004,4,21]],"date-time":"2004-04-21T15:02:34Z","timestamp":1082559754000},"page":"345-353","source":"Crossref","is-referenced-by-count":18,"title":["Histamine enhances cytotrophoblast invasion by inducing intracellular calcium transients through the histamine type\u20101 receptor"],"prefix":"10.1002","volume":"68","author":[{"given":"Zitao","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian A.","family":"Kilburn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard E.","family":"Leach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bibhash C.","family":"Paria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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