{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T07:45:13Z","timestamp":1773733513046,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,2,22]],"date-time":"2006-02-22T00:00:00Z","timestamp":1140566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Reproduction Devel"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Selection on uterine capacity has been used in animal breeding as a way to improve the litter size. A divergent selection experiment for uterine capacity was performed in rabbits during ten generations. After the first generations of selection, large differences in number of implanted embryos were obtained between high and low lines. The major part of the differences between lines was due to embryo survival. A segregation analysis suggested the presence of a major gene affecting the reproductive traits. The objective of this work was to test the TIMP\u20101 gene as a candidate gene for embryo survival in rabbits since it stands up as a target for the investigation of reproductive problems in humans. We have analyzed the parental generation of a F2 cross which consists of 8 and 14 animals from the high and low uterine capacity lines, respectively. The rabbit TIMP\u20101 gene structure and sequence has been determined, including the proximal promoter region. Despite of the absence of polymorphism between lines in the screened regions (CDS, proximal promoter, exon 1, intron 1, and exon 2), a real\u2010time RT\u2010PCR quantification of the TIMP\u20101 mRNA in oviduct has shown significant differences between high and low lines at 62 hr of gestation, just when rabbit embryos are located in the oviduct, postulating TIMP\u20101 as an interesting candidate gene to be involved in the phenotypic differences between the two rabbit lines. Mol. Reprod. Dev. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mrd.20476","type":"journal-article","created":{"date-parts":[[2006,2,23]],"date-time":"2006-02-23T07:35:54Z","timestamp":1140680154000},"page":"678-684","source":"Crossref","is-referenced-by-count":6,"title":["TIMP\u20101 as candidate gene for embryo survival in two divergent lines selected for uterine capacity in rabbits"],"prefix":"10.1002","volume":"73","author":[{"given":"Jordi","family":"Estell\u00e9","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolanda","family":"Sastre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maribel","family":"Merch\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Peir\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria A.","family":"Santacreu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep M.","family":"Folch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,2,22]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/302556"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-002-0676-8"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.2527\/1997.7592350x","article-title":"Divergent selection for uterine capacity in rabbits","volume":"75","author":"Argente MJ","year":"1997","journal-title":"J Anim Sci"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1093\/genetics\/163.3.1061","article-title":"Analyses for the presence of a major gene affecting uterine capacity in unilaterally ovariectomized does","volume":"163","author":"Argente MJ","year":"2003","journal-title":"Genetics"},{"key":"e_1_2_1_6_1","unstructured":"ArmeroQ BlascoA.1992.Economic weights for rabbit selection indices. 5th World Rabbit Congress A:637."},{"key":"e_1_2_1_7_1","unstructured":"AusubelFM BrentR KingstonRE MooreDD SeidmanJG SmithJA StruhlK.1987.Current protocols in molecular biology. 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