{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:02:51Z","timestamp":1761843771546},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,6,6]],"date-time":"2008-06-06T00:00:00Z","timestamp":1212710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Reproduction Devel"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tissue inhibitor of metalloproteinase\u20101 (TIMP\u20101) is a multifunctional protein capable of regulating a variety of biological processes in a wide array of tissue and cell types. We have previously demonstrated that TIMP\u20101 deficient mice exhibit alterations in normal uterine morphology and physiology. Most notably, absence of TIMP\u20101 is associated with an altered uterine phenotype characterized by profound branching of the uterine lumen and altered adenogenesis. To begin to assess the mechanism by which TIMP\u20101 may control these uterine events, we utilized steroid\u2010treated ovariectomized wild\u2010type and TIMP\u20101 null mice exposed to estrogen for 72 hr. Administration of estrogen to TIMP\u20101 deficient mice resulted in development of an abnormal uterine histo\u2010architecture characterized by increased endometrial gland density, luminal epithelial cell height, and abnormal lumen structure. To determine the mediators which may contribute to the abnormal uterine morphology in the TIMP\u20101 deficient mice, cDNA microarray analysis was performed. Analysis revealed that expression of two plasmin inhibitors (serpbinb2 and serbinb7) was significantly reduced in the TIMP\u20101 null mice. Associated with the reduction in expression of these inhibitors was a significant increase in plasmin activity. Localization of the novel uterine serpinb7 revealed that expression was confined to the luminal and glandular epithelial cells. Further, expression of uterine serpinb7 was decreased by estrogen and showed an inverse relationship with plasmin activity. We conclude from these studies that in addition to controlling MMP activity, TIMP\u20101 may also control activity of serine proteases through modulation of serine protease inhibitors such as serpinb7. Mol. Reprod. Dev. 76: 160\u2013172, 2009. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mrd.20938","type":"journal-article","created":{"date-parts":[[2008,6,6]],"date-time":"2008-06-06T16:23:30Z","timestamp":1212769410000},"page":"160-172","source":"Crossref","is-referenced-by-count":13,"title":["Estrogen\u2010induced uterine abnormalities in TIMP\u20101 deficient mice are associated with elevated plasmin activity and reduced expression of the novel uterine plasmin protease inhibitor serpinb7"],"prefix":"10.1002","volume":"76","author":[{"given":"Xuan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etter","family":"Hoang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warren B.","family":"Nothnick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,6,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/11.suppl_2.150"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4838(99)00279-4"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-006-7893-x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1071-5576(00)00062-9"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.2.686"},{"key":"e_1_2_1_7_1","first-page":"20","article-title":"Plasminogen activator inhibitor types 1 and 2 in human trophoblasts. PAI\u20101 is an immunohistochemical marker of invading trophoblasts","volume":"61","author":"Feinberg RF","year":"1989","journal-title":"Lab Invest"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.1140347"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/plac.1999.0446"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2000.5959"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(92)90076-U"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.141R001"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod53.2.302"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.136.11.4973"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.1999.19420183.x"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.104.031559"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/3.1.27"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.5509"},{"key":"e_1_2_1_19_1","first-page":"137","article-title":"Regulation of gene expression and cell function by extracellular matrix","volume":"3","author":"Jones PL","year":"1993","journal-title":"Crit Rev Eukaryotic Gene Expr"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a129257"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.79.2.643"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biolcel.2003.09.007"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4004(98)90006-6"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2450"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0214336"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.060002641.x"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod63.3.905"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod65.6.1780"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1530\/rep.0.1220923"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod56.5.1181"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.103.020834"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2007.07.001"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(12)90922-9"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117461"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.138.11.4902"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod59.6.1349"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-006-0289-9"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.125.3.681"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21208"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.137.12.5429"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.8.2810"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/3.9.735"}],"container-title":["Molecular Reproduction and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmrd.20938","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrd.20938","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T18:34:12Z","timestamp":1699900452000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrd.20938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,6]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["10.1002\/mrd.20938"],"URL":"https:\/\/doi.org\/10.1002\/mrd.20938","archive":["Portico"],"relation":{},"ISSN":["1040-452X","1098-2795"],"issn-type":[{"value":"1040-452X","type":"print"},{"value":"1098-2795","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,6]]}}}