{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:58:35Z","timestamp":1788872315114,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,3,29]],"date-time":"2011-03-29T00:00:00Z","timestamp":1301356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Reproduction Devel"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Uterine epithelial cells transform into a receptive state to adhere to an implanting blastocyst. Part of this transformation includes the apical concentration of cell adhesion molecules at the time of implantation. This study, for the first time, investigates the expression of ICAM1 and fibrinogen\u2010\u03b3 (FGG) in uterine epithelial cells during normal pregnancy, pseudopregnancy and in hormone\u2010treated rats. An increase (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05) in ICAM1 was seen at the apical membrane of uterine epithelial cells at the time of implantation compared with day 1 of pregnancy. ICAM1 was also increased (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05) on day 6 of pseudopregnancy as well as in ovariectomized rats treated with progesterone plus oestrogen. These results show that ICAM1 up\u2010regulation at the time of implantation is under the control of progesterone, and is not dependent on cytokine release from the blastocyst or in semen. FGG dimerization increased (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05) on day 6 of pregnancy compared with day 1, and was not up\u2010regulated in day 6 pseudopregnant animals, suggesting this increase is dependent on a developing blastocyst. The presence of ICAM1 and FGG in the uterine epithelium at the time of implantation in the rat is similar to that seen in lymphocyte\u2013endothelium adhesion, and we suggest a similar mechanism in embryo\u2013uterine epithelium adhesion is utilized. Mol. Reprod. Dev. 78:318\u2013327, 2011. \u00a9 2011 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/mrd.21307","type":"journal-article","created":{"date-parts":[[2011,3,4]],"date-time":"2011-03-04T13:56:02Z","timestamp":1299246962000},"page":"318-327","source":"Crossref","is-referenced-by-count":15,"title":["ICAM1 and fibrinogen\u2010\u03b3 are increased in uterine epithelial cells at the time of implantation in rats"],"prefix":"10.1002","volume":"78","author":[{"given":"Laura","family":"Lecce","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yui","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romanthi J.","family":"Madawala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher R.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,3,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.2.696"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1530\/ror.0.0020084"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/1999\/67137"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7643-7975-9_4"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200112126"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/HUMREP\/10.6.1571"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4004(03)00135-8"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1994.tb00853.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2006.00447.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0970083"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000110350"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-3781hyp"},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.4049\/jimmunol.137.1.245","article-title":"Induction by IL 1 and interferon\u2010gamma: Tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM1)","volume":"137","author":"Dustin ML","year":"1986","journal-title":"J Immunol"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2008.00776.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1079546"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02786454"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2003.10.043"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118825"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199106000-00024"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-1-44"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1071\/RD08148"},{"key":"e_1_2_7_23_1","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1093\/oxfordjournals.humrep.a138188","article-title":"Embryonic resistance to tumour necrosis factor\u2010alpha mediated cytotoxicity: Novel mechanism underlying maternal immunological tolerance to the fetal allograft","volume":"8","author":"Lachapelle MH","year":"1993","journal-title":"Hum Reprod"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90367-Y"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0378(01)00139-5"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1996.tb00031.x"},{"key":"e_1_2_7_27_1","first-page":"110","article-title":"Attachment reaction of rat uterine luminal epithelium. 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