{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T05:52:50Z","timestamp":1789969970192,"version":"4.0.1"},"reference-count":60,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,7,23]],"date-time":"2014-07-23T00:00:00Z","timestamp":1406073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"ANPCYT","award":["PICT 2011-2106"],"award-info":[{"award-number":["PICT 2011-2106"]}]},{"name":"ANPCYT","award":["2010-0248"],"award-info":[{"award-number":["2010-0248"]}]},{"DOI":"10.13039\/501100006449","name":"Roemmers Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006449","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Reproduction Devel"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Polycystic ovary syndrome (PCOS) is the most common endocrinological pathology among women of reproductive age, and is characterized by abnormalities in ovarian angiogenesis, among other features. Consistent with this association, follicular fluid (FF) concentration and ovarian expression of vascular endothelial growth factor (VEGF) are increased in PCOS patients. In this study, we examined the protein levels of platelet\u2010derived growth factor (PDGF) BB and DD (PDGFBB and PDGFDD), angiopoietin 1 and 2 (ANGPT1 and ANGPT2), and their soluble receptor sTIE2 in FF from PCOS and control patients undergoing assisted reproductive techniques. We also analyzed the effect of FF from PCOS and control patients on tight and adherens junction protein expression in an endothelial cell line. PDGFBB and PDGFDD were significantly lower whereas ANGPT1 concentration was significantly higher in FF from PCOS patients than from control patients. No changes were found in the concentration of ANGPT2 or sTIE2. Expression of claudin\u20105 was significantly increased in endothelial cells incubated for 24\u2009hr in the presence of FF from PCOS versus from control patients, while vascular\u2010endothelial cadherin, \u03b2\u2010catenin, and zonula occludens 1 expression were unchanged. The changes observed in the levels of PDGF isoforms and ANGPT1 may prevent VEGF\u2010induced vascular permeability in the PCOS ovary by regulating endothelial\u2010cell\u2010junction protein levels. Restoring the levels of angiogenic factors may provide new insights into PCOS treatment and the prevention of ovarian hyperstimulation syndrome in affected women.\n                      <jats:italic>Mol. Reprod. Dev<\/jats:italic>\n                      . 81: 748\u2013756, 2014. \u00a9 2014 Wiley Periodicals, Inc.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrd.22343","type":"journal-article","created":{"date-parts":[[2014,5,28]],"date-time":"2014-05-28T14:56:29Z","timestamp":1401288989000},"page":"748-756","source":"Crossref","is-referenced-by-count":34,"title":["Platelet\u2010derived growth factor BB and DD and angiopoietin1 are altered in follicular fluid from polycystic ovary syndrome patients"],"prefix":"10.1002","volume":"81","author":[{"given":"Leopoldina","family":"Scotti","sequence":"first","affiliation":[{"name":"Instituto de Biolog\u00eda y Medicina Experimental\u2014CONICET Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Parborell","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda y Medicina Experimental\u2014CONICET Buenos Aires 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