{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:06:34Z","timestamp":1791417994175,"version":"4.3.3"},"reference-count":61,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,8,22]],"date-time":"2014-08-22T00:00:00Z","timestamp":1408665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Reproduction Devel"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:sec><jats:label\/><jats:p>Preeclampsia is a pregnancy\u2010specific disorder characterized by de novo development of concurrent hypertension, proteinuria, and placental oxidative stress. During the last trimester of gestation, maternal\u2010to\u2010fetal transport of minerals is dramatically increased and becomes tightly mediated by ion channels that are highly permeable to various divalent cations, such as Ca<jats:sup>2+<\/jats:sup>, Mg<jats:sup>2+<\/jats:sup>, and Zn<jats:sup>2+<\/jats:sup>. The regulation of magnesium\/inorganic phosphorus ion\u2010channel transport in the placenta, however, is not incompletely understood. In the present study, we examined the regulation of magnesium\/inorganic phosphorus channels (MPCs) in the placenta of pregnant women suffering from preeclampsia as well as in primary human placental cells subjected to oxidative stress. The expression of MPC genes (<jats:italic>TRPM6<\/jats:italic>, <jats:italic>TRPM7<\/jats:italic>, <jats:italic>PiT\u20101<\/jats:italic>, and <jats:italic>PiT\u20102<\/jats:italic>) was down\u2010regulated in preeclamptic placenta tissues during preterm labor, and generally remained lower at term labor\u2014although <jats:italic>TRPM7<\/jats:italic> expression in the central placenta or <jats:italic>PiT\u20102<\/jats:italic> expression in whole placenta was unchanged or up\u2010regulated. Consistent with this association, expression of MPC genes in the primary placental cells was reduced under hypoxic conditions. TRPM6, TRPM7, and PiT\u20101 channels were predominantly detected in the syncytiotrophoblast layers of the placenta. In contrast, PiT\u20102 was abundant in the placental intravillous connective tissues. Taken together, our findings indicated that placental MPC expression is down\u2010regulated in cases of preeclampsia and under hypoxia. This relationship may contribute to a better understanding of the interrelationship between magnesium\/inorganic phosphorus imbalances and preeclampsia development during preterm or term labor. <jats:italic>Mol. Reprod. Dev. 81: 851\u2013860, 2014. \u00a9 2014 Wiley Periodicals, Inc<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrd.22353","type":"journal-article","created":{"date-parts":[[2014,8,22]],"date-time":"2014-08-22T13:21:50Z","timestamp":1408713710000},"page":"851-860","source":"Crossref","is-referenced-by-count":25,"title":["Comparing the expression patterns of placental magnesium\/phosphorus\u2010transporting channels between healthy and preeclamptic pregnancies"],"prefix":"10.1002","volume":"81","author":[{"given":"Hyun","family":"Yang","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Biochemistry and Molecular Biology College of Veterinary Medicine Chungbuk National University Cheongju Chungbuk Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae\u2010Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology College of Medicine Soonchunhyang University Bucheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geun\u2010Shik","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Kangwon National University Chuncheon Gangwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eui\u2010Ju","family":"Hong","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Biochemistry and Molecular Biology College of Veterinary Medicine Chungbuk National University Cheongju Chungbuk Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eui\u2010Bae","family":"Jeung","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Biochemistry and Molecular Biology College of Veterinary Medicine Chungbuk National University Cheongju Chungbuk Republic of 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