{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T18:16:50Z","timestamp":1775240210485,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,1,7]],"date-time":"2015-01-07T00:00:00Z","timestamp":1420588800000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"crossref","award":["81070534"],"award-info":[{"award-number":["81070534"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Reproduction Devel"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:sec><jats:label\/><jats:p>The molecular pathogenesis of Klinefelter Syndrome (KS) is not fully understood. The aim of this study was to determine differences in gene expression patterns between KS patients and control individuals to help identify disease\u2010related genes and biological pathways. Gene expression profiles of five KS patients and five healthy men were determined by microarray; 21 differentially expressed genes with a fold\u2010change &gt;1.5 and q\u2010value &lt;0.05 were identified between the groups. Genes associated with metabolism regulation and encoding liver fatty acid\u2010binding protein (FABP1), aldehyde dehydrogenase 1 family member L1 (ALDH1L1), and vitronectin (VTN) were the most\u2010significantly down\u2010regulated in KS, as confirmed by quantitative reverse transcription PCR. Notably, none of these differentially expressed genes are normally found on the X chromosome. Thus, our results indicate that aberrant metabolism is involved in the pathogenesis of KS. Further elucidation of the how aberrant expression of metabolism\u2010related genes affect the pathogenesis of KS may lead to the development of novel preventative and therapeutic strategies. <jats:italic>Mol. Reprod. Dev. 82: 17\u201325, 2015. \u00a9 2014 Wiley Periodicals, Inc<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrd.22438","type":"journal-article","created":{"date-parts":[[2015,1,7]],"date-time":"2015-01-07T20:56:18Z","timestamp":1420664178000},"page":"17-25","source":"Crossref","is-referenced-by-count":28,"title":["Global transcriptome analysis of peripheral blood identifies the most significantly down\u2010regulated genes associated with metabolism regulation in Klinefelter syndrome"],"prefix":"10.1002","volume":"82","author":[{"given":"Jin","family":"Huang","sequence":"first","affiliation":[{"name":"Center of Reproductive Medicine, Department of Obstetrics and Gynecology Peking University Third Hospital Beijing China"},{"name":"Key Laboratory of Assisted Reproduction Ministry of Education Beijing China"},{"name":"Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction Beijing 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