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In the present study, choriocarcinoma JAr cells were found to express <jats:italic>LGALS1<\/jats:italic>, \u2010<jats:italic>2<\/jats:italic>, \u2010<jats:italic>3<\/jats:italic>, \u2010<jats:italic>8<\/jats:italic>, \u2010<jats:italic>10<\/jats:italic>, and \u2010<jats:italic>13<\/jats:italic> mRNA and at least LGALS1, \u20103, and \u20108 protein, as determined by reverse\u2010transcriptase PCR and Western blot, respectively. The galectin mRNA signature of JAr cells thus differed from that of normal first\u2010trimester extravillous trophoblasts. A Matrigel migration assay was also used to investigate and confirm the relevance and effect of LGALS1 on the invasive potential of JAr cells, as observed in other trophoblast models. This modulation in behavior was achieved by specific lectin\u2010glycan binding. <jats:italic>Mol. Reprod. Dev. 82: 765\u2013773, 2015. \u00a9 2015 Wiley Periodicals, Inc<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrd.22515","type":"journal-article","created":{"date-parts":[[2015,6,20]],"date-time":"2015-06-20T23:19:27Z","timestamp":1434842367000},"page":"765-773","source":"Crossref","is-referenced-by-count":7,"title":["Galectin signature of the choriocarcinoma JAr cells: Galectin\u20101 as a modulator of invasiveness in vitro"],"prefix":"10.1002","volume":"82","author":[{"given":"Nikola","family":"Kolund\u017ei\u0107","sequence":"first","affiliation":[{"name":"Laboratory for Biology of Reproduction Institute INEP University of Belgrade Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danica","family":"\u0106uji\u0107","sequence":"additional","affiliation":[{"name":"Laboratory for Biology of Reproduction Institute INEP University of Belgrade Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara","family":"Abu 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