{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T11:49:13Z","timestamp":1772538553189,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T00:00:00Z","timestamp":1439164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000199","name":"U.S. Department of Agriculture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Reproduction Devel"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:sec><jats:label\/><jats:p>The microenvironment of a preimplantation embryo can influence changes in development that affect postnatal phenotypes. One of the potential mediators of this effect in many species is colony\u2010stimulating factor (CSF2), which can increase an embryo's ability to establish pregnancy after its transfer into recipients. Exposure of embryos to CSF2 during early development can also affect the pattern of development later in pregnancy in a sex\u2010dependent manner. We therefore hypothesized that treatment of in vitro\u2010produced embryos with CSF2 in culture would alter birth weight and postnatal growth of the resultant calf. Body weight and withers height were measured for Holstein heifer calves produced in vitro with or without 10\u2009ng\/ml CSF2 and for calves produced by artificial insemination. There were no differences in birth weight between groups; thereafter, however, calves from the CSF2\u2010treated group experienced greater increases in body weight through 13 months of age, with only small differences in withers height. These results support the model that an embryo's postnatal characteristics can be programmed during the preimplantation period, and that CSF2 is one of the embryokines through which programming is directed. <jats:italic>Mol. Reprod. Dev. 82: 892\u2013897, 2015. \u00a9 2015 Wiley Periodicals, Inc<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrd.22533","type":"journal-article","created":{"date-parts":[[2015,7,29]],"date-time":"2015-07-29T14:50:10Z","timestamp":1438181410000},"page":"892-897","source":"Crossref","is-referenced-by-count":43,"title":["Exposure to colony stimulating factor 2 during preimplantation development increases postnatal growth in cattle"],"prefix":"10.1002","volume":"82","author":[{"given":"Jasmine","family":"Kannampuzha\u2010Francis","sequence":"first","affiliation":[{"name":"Department of Animal Sciences University of Florida  Gainesville  Florida"},{"name":"D. H. Barron Reproductive and Perinatal Biology Research Program University of Florida Gainesville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna C.","family":"Denicol","sequence":"additional","affiliation":[{"name":"Department of Biology Northeastern University Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Loureiro","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Universidade Vila Velha Vila Velha Espirito Santo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karun","family":"Kaniyamattam","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences University of Florida  Gainesville  Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Sofia","family":"Ortega","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences University of Florida  Gainesville  Florida"},{"name":"D. H. Barron Reproductive and Perinatal Biology Research Program University of Florida Gainesville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences University of Florida  Gainesville  Florida"},{"name":"D. H. Barron Reproductive and Perinatal Biology Research Program University of Florida Gainesville Florida"},{"name":"Genetics Institute University of Florida Gainesville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1305609111"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2003.11.005"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-253112"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.113.113183"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.114.121087"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a135899"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2014.05.017"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2010.08.020"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.19.4195"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.22143"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0481"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod57.5.1060"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2013.03.014"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1530\/rep.1.00160"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1071\/RD06137"},{"key":"e_1_2_6_17_1","first-page":"425","article-title":"Colony\u2010stimulating factor 2 affects development of the bovine preimplantation embryo differently for female than males","volume":"93","author":"Siqueira L","year":"2015","journal-title":"J Anim Sci"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-1260"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.12.3069"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod58.5.1217"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.107.064220"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7007-9-49"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.12.043"}],"container-title":["Molecular Reproduction and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmrd.22533","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrd.22533","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mrd.22533","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrd.22533","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T15:40:48Z","timestamp":1696347648000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrd.22533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,10]]},"references-count":22,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1002\/mrd.22533"],"URL":"https:\/\/doi.org\/10.1002\/mrd.22533","archive":["Portico"],"relation":{},"ISSN":["1040-452X","1098-2795"],"issn-type":[{"value":"1040-452X","type":"print"},{"value":"1098-2795","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,10]]}}}