{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:43:17Z","timestamp":1787244197817,"version":"build-2736575974"},"reference-count":109,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T00:00:00Z","timestamp":1456876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Key Technology Support Program of 530 China","award":["2011BAD28B01"],"award-info":[{"award-number":["2011BAD28B01"]}]},{"name":"Hubei Province Major Technology Innovation Program of China","award":["2014ABA025"],"award-info":[{"award-number":["2014ABA025"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Reproduction Devel"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Significant tissue destruction, repair, and remodeling are involved in parturition, which involves fetal membrane rupture, cervical ripening, and uterine contraction and its subsequent involution. Extracellular matrix degradation and remodeling by proteolytic enzymes, such as matrix metalloproteinases (MMPs), are required for the final steps of parturition. MMPs participate in physiological degradation and remodeling through their proteolytic activities on specific substrates, and are balanced by the action of their inhibitors. Disruption to this balance can result in pathological stress that ends with preterm or post\u2010term birth or pre\u2010eclampsia. In this review, we examine the roles and regulation of the MMP system in physiological and pathological labor, and propose a model that illustrates the mechanisms by which the MMP system contributes to these processes.\n                      <jats:italic>Mol. Reprod. Dev. 83: 276\u2013286, 2016. \u00a9 2016 Wiley Periodicals, Inc<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrd.22626","type":"journal-article","created":{"date-parts":[[2016,2,18]],"date-time":"2016-02-18T04:43:13Z","timestamp":1455770593000},"page":"276-286","source":"Crossref","is-referenced-by-count":34,"title":["Roles and regulation of the matrix metalloproteinase system in parturition"],"prefix":"10.1002","volume":"83","author":[{"given":"Junnan","family":"Geng","sequence":"first","affiliation":[{"name":"Key Laboratory of Swine Genetics and Breeding of Agricultural Ministry College of Animal Science and Technology Huazhong Agricultural University Wuhan China"},{"name":"The Cooperative Innovation Center for Sustainable Pig Production Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Swine Genetics and Breeding of Agricultural Ministry College of Animal Science and Technology Huazhong Agricultural University Wuhan China"},{"name":"The Cooperative Innovation Center for Sustainable Pig Production Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwen","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Swine Genetics and Breeding of Agricultural Ministry College of Animal Science and Technology Huazhong Agricultural University Wuhan China"},{"name":"The Cooperative Innovation Center for Sustainable Pig Production Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gah025"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.102.004721"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6661(199909\/10)8:5<213::AID-MFM3>3.0.CO;2-R"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.03.023"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-6-45"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.06.103"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod57.4.908"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4838(99)00279-4"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4004(98)90092-3"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod63.6.1575b"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2004.08.002"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/316146"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2006.07.024"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2008.08.009"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.11.026"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.54.4.1069"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod64.5.1285"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2002-0005"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2010.11.019"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2005.00580.x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2013.07.001"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(84)90677-X"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gag040"},{"key":"e_1_2_10_25_1","first-page":"111","article-title":"Tissue inhibitors of metalloproteinases: Structure, regulation and biological functions","volume":"74","author":"Gomez DE","year":"1997","journal-title":"Eur J Cell Biol"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767050802127349"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.55.070186.002411"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.123034"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719111413299"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)98804-6"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod56.3.575"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-010-1365-9"},{"key":"e_1_2_10_33_1","first-page":"115","article-title":"Effects of endothelin\u20101 and calcium channel blockers on contractions in human myometrium. 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