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In our study, we found that a high concentration of NP could down\u2010regulate the expression of microRNA\u2010361\u20103p (miR\u2010361\u20103p) in the murine GC\u20101 spermatogonia cell line and in vivo in murine spermatogonia. Additionally, one direct target of this miR, the 3\u2032 untranslated region <jats:italic>of Killin<\/jats:italic> (<jats:italic>Klln<\/jats:italic>) mRNA, was identified. <jats:italic>Klln<\/jats:italic> encodes a transcription factor that directly regulates the expression of <jats:italic>Tp73<\/jats:italic> (transcriptionally active p73), whose encoded protein can up\u2010regulate the expression of <jats:italic>Puma<\/jats:italic> (<jats:italic>p53<\/jats:italic> upregulated modulator of apoptosis). Thus, our investigation revealed that the expression of <jats:italic>Klln<\/jats:italic>, <jats:italic>Tp73<\/jats:italic>, and <jats:italic>Puma<\/jats:italic> increased upon NP\u2010dependent down\u2010regulation of miR\u2010361\u20103p, which eventually leads to apoptosis of spermatogonia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrd.22923","type":"journal-article","created":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T14:36:38Z","timestamp":1507818998000},"page":"1257-1270","source":"Crossref","is-referenced-by-count":9,"title":["Regulation of nonylphenol\u2010induced reproductive toxicity in mouse spermatogonia cells by miR\u2010361\u20103p"],"prefix":"10.1002","volume":"84","author":[{"given":"Liyan","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Urology Baoji People's Hospital Baoji Shananxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Urology Baoji People's Hospital Baoji Shananxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology Baoji People's Hospital Baoji Shananxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiao","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Urology Baoji People's Hospital Baoji Shananxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Urology Baoji People's Hospital Baoji Shananxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhijiang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Urology Baoji People's Hospital Baoji Shananxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ce","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology Baoji People's Hospital Baoji Shananxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Urology Baoji People's Hospital Baoji Shananxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiyuan","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Urology Baoji People's Hospital Baoji Shananxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenbing","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Urology Baoji People's Hospital Baoji Shananxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaohua","family":"Bian","sequence":"additional","affiliation":[{"name":"Department of Urology Baoji People's Hospital Baoji Shananxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang","family":"Bi","sequence":"additional","affiliation":[{"name":"Department of Urology Baoji People's Hospital Baoji Shananxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huimin","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Urology, Xijing Hospital the Fourth Military Medical University Xi'an Shananxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0895-6803","authenticated-orcid":false,"given":"Yingyi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology Baoji People's Hospital Baoji Shananxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2012.02.015"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00045-5"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2013.01.061"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705410105"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-9-126"},{"key":"e_1_2_8_7_1","first-page":"347","article-title":"Biotransformation, tissue distribution, and persistence of 4\u2010nonylphenol residues in juvenile rainbow trout (Oncorhynchus mykiss)","volume":"26","author":"Coldham N. 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