{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T05:05:49Z","timestamp":1776661549738,"version":"3.51.2"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T00:00:00Z","timestamp":1519689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31301977"],"award-info":[{"award-number":["31301977"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005196","name":"Chinese Academy of Agricultural Sciences","doi-asserted-by":"publisher","award":["2017ywf\u2010zd\u20108"],"award-info":[{"award-number":["2017ywf\u2010zd\u20108"]}],"id":[{"id":"10.13039\/501100005196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005196","name":"Chinese Academy of Agricultural Sciences","doi-asserted-by":"publisher","award":["2011cj\u201011"],"award-info":[{"award-number":["2011cj\u201011"]}],"id":[{"id":"10.13039\/501100005196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Reproduction Devel"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec><jats:label\/><jats:p>Neonatal respiratory distress is a major mortality factor in cloned animals, but the pathogenesis of this disease is rarely investigated. In this study, four neonatal cloned cattle, born after full\u2010term gestation, exhibited symptoms of neonatal respiratory distress syndrome (NRDS), which included symptoms of hyaline membrane disease as well as disordered surfactant homeostasis in their collapsed lungs. No differences in DNA methylation or histone modifications correlated with the suppressed <jats:italic>SPB<\/jats:italic> and <jats:italic>SPC<\/jats:italic> transcription observed in the cloned cattle group (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05), whereas TTF\u20101 occupancy at <jats:italic>SPB<\/jats:italic> and <jats:italic>SPC<\/jats:italic> promoter regions in cloned cattle was significantly reduced to 24% and 20% that of normal lungs, respectively (<jats:italic>SPB<\/jats:italic>, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05; <jats:italic>SPC<\/jats:italic>, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Decreased <jats:italic>TTF1<\/jats:italic> expression, dysregulation of <jats:italic>SPB<\/jats:italic> and <jats:italic>SPC<\/jats:italic> transcription by TTF\u20101, and disordered proteolytic processing of Surfactant protein B precursor together potentially contribute to the disruption of surfactant homeostasis and NRDS in bovine clones. Elucidation of the associated mechanisms should facilitate the development of novel preventive or therapeutic strategies to reduce the mortality rate of cloned animals and to improve the efficiency of SCNT technology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrd.22956","type":"journal-article","created":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T13:06:41Z","timestamp":1517490401000},"page":"227-235","source":"Crossref","is-referenced-by-count":4,"title":["Neonatal respiratory distress syndrome and underlying mechanisms in cloned cattle"],"prefix":"10.1002","volume":"85","author":[{"given":"Yifan","family":"Rao","sequence":"first","affiliation":[{"name":"Institute of Animal Sciences Chinese Academy of Agricultural Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuzhu","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Northwest A&amp;F University Yangling China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Yang","sequence":"additional","affiliation":[{"name":"Laboratory of Zoonosis of Liaoning Province, College of Animal Science &amp; Veterinary Medicine Shenyang Agricultural University Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Animal Sciences Chinese Academy of Agricultural Sciences Beijing China"},{"name":"College of Biological Sciences China Agricultural University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojing","family":"Jiang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Northwest A&amp;F University Yangling China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linhua","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Northwest A&amp;F University Yangling China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaogai","family":"Guo","sequence":"additional","affiliation":[{"name":"Laboratory of Zoonosis of Liaoning Province, College of Animal Science &amp; Veterinary Medicine Shenyang Agricultural University Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weihua","family":"Du","sequence":"additional","affiliation":[{"name":"Institute of Animal Sciences Chinese Academy of Agricultural Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haisheng","family":"Hao","sequence":"additional","affiliation":[{"name":"Institute of Animal Sciences Chinese Academy of Agricultural Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueming","family":"Zhao","sequence":"additional","affiliation":[{"name":"Institute of Animal Sciences Chinese Academy of Agricultural Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuling","family":"Jiang","sequence":"additional","affiliation":[{"name":"Institute of Animal Sciences Chinese Academy of Agricultural Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8452-7181","authenticated-orcid":false,"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Animal Sciences Chinese Academy of Agricultural Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2165\/00151829-200504060-00006"},{"issue":"5","key":"e_1_2_7_3_1","first-page":"517","article-title":"Surface properties in relation to atelectasis and hyaline membrane disease","volume":"97","author":"Avery M. E.","year":"1959","journal-title":"American Journal of Diseases of Children"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.14.9.5671"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2011.0693.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/380064a0"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/153623002320253319"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.73.3.F125"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M304885200"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2015.11.002"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.101500298"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.146332"},{"issue":"10","key":"e_1_2_7_13_1","first-page":"1","article-title":"Deaths: Leading causes for 2012","volume":"64","author":"Heron M.","year":"2015","journal-title":"National Vital Statistics Reports"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.12.6881"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.115.136051"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114000"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.22836"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/clo.2008.0015"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/cell.2015.0024"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00011.2003"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod67.1.334"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/cell.2010.0004"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001340050019"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201103-0495PP"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.60.041807.123500"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-012513-104644"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/385810a0"}],"container-title":["Molecular Reproduction and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmrd.22956","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrd.22956","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T03:22:39Z","timestamp":1695698559000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrd.22956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,27]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1002\/mrd.22956"],"URL":"https:\/\/doi.org\/10.1002\/mrd.22956","archive":["Portico"],"relation":{},"ISSN":["1040-452X","1098-2795"],"issn-type":[{"value":"1040-452X","type":"print"},{"value":"1098-2795","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,27]]}}}