{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T11:12:30Z","timestamp":1773745950130,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"8-9","license":[{"start":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T00:00:00Z","timestamp":1537833600000},"content-version":"vor","delay-in-days":55,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/nd\/4.0\/"}],"funder":[{"name":"Androvia LifeSciences LLC"},{"name":"New York City Partnership Fund's BioAccelerate NYC Prize"},{"name":"Cornell University's Baker Institute for Animal Health"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Reproduction Devel"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:p>\n                    Semen analysis (SA) poorly predicts male fertility, because it does not assess sperm fertilizing ability. The percentage of capacitated sperm determined by G\n                    <jats:sub>M1<\/jats:sub>\n                    localization (\u201cCap\u2010Score\u2122\u201d), differs between cohorts of fertile and potentially infertile men, and retrospectively, between men conceiving or failing to conceive by intrauterine insemination (IUI). Here, we prospectively tested whether Cap\u2010Score can predict male fertility with the outcome being clinical pregnancy within \u22643 IUI cycles. Cap\u2010Score and SA were performed (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009208) with outcomes initially available for 91 men. Men were predicted to have either low (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200947) or high (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200944) chance of generating pregnancy using previously\u2010defined Cap\u2010Score reference ranges. Absolute and cumulative pregnancy rates were reduced in men predicted to have low pregnancy rates versus high ([absolute: 10.6% vs. 29.5%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.04]; [cumulative: 4.3% vs. 18.2%, 9.9% vs. 29.1%, and 14.0% vs. 32.8% for cycles 1\u20133;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200991, 64, and 41;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02]). Only Cap\u2010Score, not male\/female age or SA results, differed significantly between outcome groups. Logistic regression evaluated Cap\u2010Score and SA results relative to the probability of generating pregnancy (PGP) for men who were successful in, or completed, three IUI cycles (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200957). Cap\u2010Score was significantly related to PGP (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.01). The model fit was then tested with 67 additional patients (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009124; five clinics); the equation changed minimally, but fit improved (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001; margin of error: 4%). The Akaike Information Criterion found the best model used Cap\u2010Score as the only predictor. These data show that Cap\u2010Score provides a practical, predictive assessment of male fertility, with applications in assisted reproduction and treatment of male infertility.\n                  <\/jats:p>","DOI":"10.1002\/mrd.23057","type":"journal-article","created":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T04:48:36Z","timestamp":1536209316000},"page":"654-664","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Cap\u2010Score\u2122 prospectively predicts probability of pregnancy"],"prefix":"10.1002","volume":"85","author":[{"given":"Jay","family":"Schinfeld","sequence":"first","affiliation":[{"name":"Abington Reproductive Medicine Abington Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fady","family":"Sharara","sequence":"additional","affiliation":[{"name":"Virginia Center for Reproductive Medicine Reston Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randy","family":"Morris","sequence":"additional","affiliation":[{"name":"IVF1 Naperville Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianpiero D.","family":"Palermo","sequence":"additional","affiliation":[{"name":"The Ronald O. Perelman &amp; Claudia Cohen Center for Reproductive Medicine &amp; Infertility, Weill Cornell Medical College  New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zev","family":"Rosenwaks","sequence":"additional","affiliation":[{"name":"The Ronald O. Perelman &amp; Claudia Cohen Center for Reproductive Medicine &amp; Infertility, Weill Cornell Medical College  New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Seaman","sequence":"additional","affiliation":[{"name":"New Jersey Urology Millburn New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Hirshberg","sequence":"additional","affiliation":[{"name":"Urology Health Specialists Abington Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Cook","sequence":"additional","affiliation":[{"name":"Singular Value Consulting Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Cardona","sequence":"additional","affiliation":[{"name":"Androvia LifeSciences Mountainside New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3951-512X","authenticated-orcid":false,"given":"G. Charles","family":"Ostermeier","sequence":"additional","affiliation":[{"name":"Androvia LifeSciences Mountainside New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5010-7568","authenticated-orcid":false,"given":"Alexander J.","family":"Travis","sequence":"additional","affiliation":[{"name":"Androvia LifeSciences Mountainside New Jersey"},{"name":"Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University Ithaca New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,25]]},"reference":[{"key":"e_1_2_9_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)01641-1"},{"key":"e_1_2_9_1_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-015-0032-1"},{"key":"e_1_2_9_1_4_1","first-page":"pp. 255","volume-title":"Assisted reproductive technology: accomplishments and new horizons","author":"Aitken R. 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