{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T11:16:49Z","timestamp":1779362209687,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T00:00:00Z","timestamp":1548115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270943"],"award-info":[{"award-number":["81270943"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471077"],"award-info":[{"award-number":["81471077"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600678"],"award-info":[{"award-number":["81600678"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670733"],"award-info":[{"award-number":["81670733"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Reproduction Devel"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p>Polycystic ovary syndrome (PCOS) is the most common endocrinopathy and an important metabolic disorder in women of reproductive age. Insulin resistance (IR) is one of its most important clinical features in patients with PCOS. Androgen excess\u2010induced mitochondrial dysfunction contributes to skeletal muscle IR in dehydroepiandrosterone (DHEA)\u2010induced PCOS mice. The effect of androgen excess on the skeletal muscle, however, is incompletely characterized. A nontargeted metabolomics approach was thus applied to analyze the metabolites in skeletal muscle of DHEA\u2010induced PCOS mice. Data from metabolomic analysis revealed the significant changes in 32 metabolites and the marked impact of five metabolic pathways. ATP production was also found to be significantly reduced in skeletal muscle of DHEA mice. Combined with the quantification of type I and II myofibers and lipid measurement in the skeletal muscle of the mice, the results from the present study supported the role of mitochondrial impairment rather than lipid accumulation in the pathogenesis of skeletal muscle IR in DHEA\u2010induced PCOS mice. In summary, we show here for the first time the profile of the metabolites in the skeletal muscle of DHEA\u2010induced PCOS mice which exhibit IR. The work would help better understand the pathology of skeletal muscle IR in PCOS.<\/jats:p>","DOI":"10.1002\/mrd.23111","type":"journal-article","created":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T17:29:38Z","timestamp":1547227778000},"page":"370-378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Nontargeted metabolomic analysis of skeletal muscle in a dehydroepiandrosterone\u2010induced mouse model of polycystic ovary syndrome"],"prefix":"10.1002","volume":"86","author":[{"given":"Qiyang","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Physiology and Pathophysiology School of Basic Medical Sciences, Peking University Health Science Center Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai","family":"Bi","sequence":"additional","affiliation":[{"name":"Department of Urology Peking University Third Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuhai","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology School of Basic Medical Sciences, Peking University Health Science Center Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liting","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology School of Basic Medical Sciences, Peking University Health Science Center Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Menliang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology School of Basic Medical Sciences, Peking University Health Science Center Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Jia","sequence":"additional","affiliation":[{"name":"Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0973-9632","authenticated-orcid":false,"given":"Jihong","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology School of Basic Medical Sciences, Peking University Health Science Center Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,22]]},"reference":[{"key":"e_1_2_7_1_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00367.2006"},{"key":"e_1_2_7_1_3_1","article-title":"Associations between vitamin D levels and polycystic ovary syndrome (PCOS) phenotypes","author":"Davis E. M.","year":"2018","journal-title":"Minerva Endocrinologica"},{"key":"e_1_2_7_1_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0278"},{"key":"e_1_2_7_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-70178-3_26"},{"key":"e_1_2_7_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2018.24"},{"key":"e_1_2_7_1_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.5b00840"},{"key":"e_1_2_7_1_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1479164118758580"},{"key":"e_1_2_7_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2442-8"},{"key":"e_1_2_7_1_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e318176b8ad"},{"issue":"10","key":"e_1_2_7_1_11_1","first-page":"765","article-title":"Associations of vitamin D concentration with metabolic and hormonal indices in women with polycystic ovary syndrome presenting abdominal and gynoidal type of obesity","volume":"85","author":"Kozakowski J.","year":"2014","journal-title":"Ginekologia Polska"},{"key":"e_1_2_7_1_12_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.114.120063"},{"key":"e_1_2_7_1_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-0790"},{"key":"e_1_2_7_1_14_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.24190"},{"key":"e_1_2_7_1_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des463"},{"key":"e_1_2_7_1_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-3876"},{"key":"e_1_2_7_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2017.04.005"}],"container-title":["Molecular Reproduction and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmrd.23111","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrd.23111","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mrd.23111","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrd.23111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T16:43:04Z","timestamp":1694364184000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrd.23111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,22]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1002\/mrd.23111"],"URL":"https:\/\/doi.org\/10.1002\/mrd.23111","archive":["Portico"],"relation":{},"ISSN":["1040-452X","1098-2795"],"issn-type":[{"value":"1040-452X","type":"print"},{"value":"1098-2795","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,22]]},"assertion":[{"value":"2018-10-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}