{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T23:42:50Z","timestamp":1771630970445,"version":"3.50.1"},"reference-count":64,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T00:00:00Z","timestamp":1548201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Reproduction Devel"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>Drugs such as oral contraceptives and hormone replacement therapies are known to find their way into rivers, lakes and seas, and have the potential to affect reproduction and development of the wildlife. The knowledge of the reproductive mechanisms and their regulation in aquatic species is of fundamental importance for predicting and preventing the damage by the increasing release of such chemicals in the environment. Mifepristone, a synthetic steroid used as a drug for chemical abortion, works by blocking the effects of progesterone. Its presence in fresh and salt water has been reported, representing a danger for aquatic species. In this frame, we evaluated in both acute and chronic exposures, the effects of mifepristone on the reproductive performance of the sea urchin <jats:italic>P. lividus<\/jats:italic>. In both acute and chronic exposures, mifepristone did not affect the histological structure of the gonads. However, mifepristone administered to females caused the decrease of the percentage of normal developed plutei larvae compared with the control, whereas it did not alter sperm motility parameters and fertilization success in males. The immunohistological localization of progesterone receptor\u2010like immunoreactivity on the plasma membrane of oocytes and ova and the molecular weight of a progesterone receptor\u2010like immunoband identified by western blotting, are in agreement with a membrane progesterone receptor deducted from the genome sequence of the sea urchin \n<jats:italic>Strongylocentrotus purpuratus<\/jats:italic> and suggest that in \n<jats:italic>P. lividus<\/jats:italic> mifepristone actions may be mediated by a progesterone receptor.<\/jats:p>","DOI":"10.1002\/mrd.23112","type":"journal-article","created":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T03:04:42Z","timestamp":1547435082000},"page":"1348-1356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Mifepristone affects fertility and development in the sea urchin <i>Paracentrotus lividus<\/i>"],"prefix":"10.1002","volume":"86","author":[{"given":"Adele","family":"Fabbrocini","sequence":"first","affiliation":[{"name":"National Research Council (CNR) Institute of Marine Sciences, UOS Napoli, Calata Porta di Massa  Napoli Italy"},{"name":"Institute for Biological Resources and Marine Biotechnologies UOS Lesina  Lesina (FG) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Coccia","sequence":"additional","affiliation":[{"name":"Department of Sciences and Technology University of Sannio  Benevento Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"D\u2019Adamo","sequence":"additional","affiliation":[{"name":"National Research Council (CNR) Institute of Marine Sciences, UOS Napoli, Calata Porta di Massa  Napoli Italy"},{"name":"Institute for Biological Resources and Marine Biotechnologies UOS Lesina  Lesina (FG) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Faggio","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences Viale Ferdinando Stagno d'Alcontres  Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1784-3843","authenticated-orcid":false,"given":"Marina","family":"Paolucci","sequence":"additional","affiliation":[{"name":"Department of Sciences and Technology University of Sannio  Benevento Italy"},{"name":"National Research Council (CNR) Institute of Food Science  Avellino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,23]]},"reference":[{"key":"e_1_2_7_1_2_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-14-0576"},{"key":"e_1_2_7_1_3_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.110.087411"},{"key":"e_1_2_7_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2014.04.011"},{"key":"e_1_2_7_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2015.01.024"},{"key":"e_1_2_7_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2007.01.682"},{"key":"e_1_2_7_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/1043-2760(91)90030-Q"},{"key":"e_1_2_7_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2013.09.033"},{"key":"e_1_2_7_1_9_1","first-page":"pp. 313","volume-title":"Paracentrotus lividus","author":"Boudouresque C. 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