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However, there is not enough information about the role of ER stress in lipopolysaccharide (LPS)\u2010induced apoptosis and inflammatory cytokine secretion in the uterus. In this study, we found that LPS induced apoptosis and inflammation in goat endometrial stromal cells (ESCs). LPS treatment inhibited cell viability and cell proliferation. In addition, the genes associated with proliferation, such as proliferating cell nuclear antigen and MKI67, were affected by LPS treatment. Moreover, LPS increased the secretion of interleukin (IL)\u20101\u03b2 and IL\u20108, promoting the levels of MYD88, caspase1, and TRL4. The 4\u2010phenylbutyric acid pretreatment inhibited the expression of unfolded protein response proteins and the secretion of inflammatory cytokines in LPS\u2010treated cells. However, blockage of inositol\u2010requiring enzyme 1 and activating transcription factor 6 did not significantly reduce apoptosis and inflammatory cytokine secretion. Collectively, ER stress involved in LPS\u2010induced apoptosis and inflammatory cytokine increased in goat ESCs. This study provides new insight into the function of ER stress in the pathological process.<\/jats:p>","DOI":"10.1002\/mrd.23152","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T07:39:41Z","timestamp":1556696381000},"page":"908-921","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Endoplasmic reticulum stress is involved in lipopolysaccharide\u2010induced inflammatory response and apoptosis in goat endometrial stromal cells"],"prefix":"10.1002","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4519-8132","authenticated-orcid":false,"given":"Amira Abdalla Abdelshafy","family":"Mohamed","sequence":"first","affiliation":[{"name":"Key Laboratory of Animal Biotechnology of the Ministry of Agriculture College of Veterinary Medicine, Northwest A&amp;F University Yangling Shaanxi China"},{"name":"Department of Animal Production College of Environmental Agricultural 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