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Fertilization is a successive, multistep, and extremely complicated event that usually includes sperm survival in the uterus, sperm migration through the uterotubal junction (UTJ) and the oviduct, sperm penetration through the cumulus cell layer and the zona pellucida, and sperm\u2013egg fusion. There may be a complex molecular mechanism to ensure that the above processes run smoothly. Previous studies have discovered essential factors for these fertilization steps through in vitro fertilization experiments. However, recent gene disruption approaches in mice have revealed that many of the factors previously described as important for fertilization are largely dispensable in gene\u2010knockout animals, and some previously unknown factors are emerging. As a result, the molecular mechanisms of fertilization, especially sperm migration from the uterus into the oviduct, have recently been revised by the emergence of genetically modified animals. In this review, we only focus on and update the essential genes for sperm migration through the UTJ and describe recent advances in our knowledge of the basis of mammalian sperm migration.<\/jats:p>","DOI":"10.1002\/mrd.23180","type":"journal-article","created":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T06:42:56Z","timestamp":1558939376000},"page":"935-955","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["An update of the regulatory factors of sperm migration from the uterus into the oviduct by genetically manipulated mice"],"prefix":"10.1002","volume":"86","author":[{"given":"Wenfeng","family":"Xiong","sequence":"first","affiliation":[{"name":"State Key Laboratory of Medical Genomics, Research Center for Experimental Medicine Shanghai Rui\u2010Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"School of Life Sciences and Biochemistry Shanghai Jiao Tong 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