{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:03:42Z","timestamp":1790226222199,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T00:00:00Z","timestamp":1571011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["No. BK20151322"],"award-info":[{"award-number":["No. BK20151322"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 31672490\/C1703"],"award-info":[{"award-number":["No. 31672490\/C1703"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Reproduction Devel"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>N6<\/jats:italic>\u2010methyladenosine (m<jats:sup>6<\/jats:sup>A) plays a key role in regulating gene expression in myriad organisms. Diapause is an important plastic phenotype that allows insects to survive under specific environmental conditions. However, the diapause molecular mechanism remains unknown. In this study, we analyzed the phylogenetics of genes related to the m<jats:sup>6<\/jats:sup>A modification complex in the silkworm (<jats:italic>Bombyx mori<\/jats:italic>) based on identified sequences from other organisms. We detected the expression of these genes during different developmental phases from four strains with different voltinism. We also determined total m<jats:sup>6<\/jats:sup>A content in cells treated with different diapause hormone concentrations or eggs exposed to hydrochloric acid. Our data revealed that m<jats:sup>6<\/jats:sup>A\u2010modification\u2010related gene expression and m<jats:sup>6<\/jats:sup>A content were greater in diapause\u2010destinated compared to nondiapause\u2010destined strains. Our findings suggest that m<jats:sup>6<\/jats:sup>A modification may provide significant epigenetic regulation of diapause\u2010related genes in the silkworm.<\/jats:p>","DOI":"10.1002\/mrd.23283","type":"journal-article","created":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T06:58:29Z","timestamp":1571122709000},"page":"1981-1992","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The role of <i>N6<\/i>\u2010methyladenosine modification on diapause in silkworm (<i>Bombyx mori<\/i>) strains that exhibit different voltinism"],"prefix":"10.1002","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3539-3292","authenticated-orcid":false,"given":"Tao","family":"Jiang","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory of Sericultural Biology and Biotechnology, School of Biotechnology Jiangsu University of Science and Technology  Zhenjiang Jiangsu China"},{"name":"Key Laboratory of Silkworm and Mulberry Genetic Improvement, Ministry of Agriculture, Sericultural Research Institute Chinese Academy of Agricultural Sciences  Zhenjiang Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiashuang","family":"Li","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Sericultural Biology and Biotechnology, School of Biotechnology Jiangsu University of Science and Technology  Zhenjiang Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Qian","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Sericultural Biology and Biotechnology, School of Biotechnology Jiangsu University of Science and Technology  Zhenjiang Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Xue","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Sericultural Biology and Biotechnology, School of Biotechnology Jiangsu University of Science and Technology  Zhenjiang Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Xu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Sericultural Biology and Biotechnology, School of Biotechnology Jiangsu University of Science and Technology  Zhenjiang Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanrong","family":"Chen","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Sericultural Biology and Biotechnology, School of Biotechnology Jiangsu University of Science and Technology  Zhenjiang Jiangsu China"},{"name":"Key Laboratory of Silkworm and Mulberry Genetic Improvement, Ministry of Agriculture, Sericultural Research Institute Chinese Academy of Agricultural Sciences  Zhenjiang Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Sericultural Biology and Biotechnology, School of Biotechnology Jiangsu University of Science and Technology  Zhenjiang Jiangsu China"},{"name":"Key Laboratory of Silkworm and Mulberry Genetic Improvement, Ministry of Agriculture, Sericultural Research Institute Chinese Academy of Agricultural Sciences  Zhenjiang Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunming","family":"Tang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Sericultural Biology and Biotechnology, School of Biotechnology Jiangsu University of Science and Technology  Zhenjiang Jiangsu China"},{"name":"Key Laboratory of Silkworm and Mulberry Genetic Improvement, Ministry of Agriculture, Sericultural Research Institute Chinese Academy of Agricultural Sciences  Zhenjiang Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoling","family":"Zhao","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Sericultural Biology and Biotechnology, School of Biotechnology Jiangsu University of Science and Technology  Zhenjiang Jiangsu China"},{"name":"Key Laboratory of Silkworm and Mulberry Genetic Improvement, Ministry of Agriculture, Sericultural Research Institute Chinese Academy of Agricultural Sciences  Zhenjiang Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heying","family":"Qian","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Sericultural Biology and Biotechnology, School of Biotechnology Jiangsu University of Science and Technology  Zhenjiang Jiangsu China"},{"name":"Key Laboratory of Silkworm and Mulberry Genetic Improvement, Ministry of Agriculture, Sericultural Research Institute Chinese Academy of Agricultural Sciences  Zhenjiang Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingjia","family":"Shen","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Sericultural Biology and Biotechnology, School of Biotechnology Jiangsu University of Science and Technology  Zhenjiang Jiangsu China"},{"name":"Key Laboratory of Silkworm and Mulberry Genetic Improvement, Ministry of Agriculture, Sericultural Research Institute Chinese Academy of Agricultural Sciences  Zhenjiang Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,14]]},"reference":[{"key":"e_1_2_7_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.16"},{"key":"e_1_2_7_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2014.09.019"},{"key":"e_1_2_7_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00360-008-0286-4"},{"key":"e_1_2_7_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5967.2008.00139.x"},{"key":"e_1_2_7_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11112"},{"key":"e_1_2_7_1_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/2.10.1653"},{"key":"e_1_2_7_1_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky156"},{"key":"e_1_2_7_1_9_1","doi-asserted-by":"publisher","DOI":"10.1261\/rna.061044.117"},{"key":"e_1_2_7_1_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3724"},{"key":"e_1_2_7_1_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-ento-112408-085436"},{"key":"e_1_2_7_1_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/1791300b0"},{"key":"e_1_2_7_1_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature20577"},{"key":"e_1_2_7_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.08.003"},{"key":"e_1_2_7_1_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/dgd.12589"},{"key":"e_1_2_7_1_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15737"},{"key":"e_1_2_7_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinsphys.2005.09.008"},{"key":"e_1_2_7_1_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/4.1.63"},{"key":"e_1_2_7_1_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature20568"},{"key":"e_1_2_7_1_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3453"},{"key":"e_1_2_7_1_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1432"},{"key":"e_1_2_7_1_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21022"},{"key":"e_1_2_7_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.05.003"},{"key":"e_1_2_7_1_24_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genet-120417-031522"},{"key":"e_1_2_7_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2012.12.006"},{"key":"e_1_2_7_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.05.045"},{"key":"e_1_2_7_1_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep11197"},{"key":"e_1_2_7_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpb.2012.01.002"},{"key":"e_1_2_7_1_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2017.15"},{"key":"e_1_2_7_1_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep15566"},{"key":"e_1_2_7_1_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2008.11.004"},{"key":"e_1_2_7_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2017.05.011"},{"key":"e_1_2_7_1_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.01.012"},{"key":"e_1_2_7_1_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1910(66)90082-5"},{"key":"e_1_2_7_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.10.015"}],"container-title":["Molecular Reproduction and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrd.23283","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mrd.23283","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrd.23283","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T20:03:50Z","timestamp":1694030630000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrd.23283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,14]]},"references-count":34,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1002\/mrd.23283"],"URL":"https:\/\/doi.org\/10.1002\/mrd.23283","archive":["Portico"],"relation":{},"ISSN":["1040-452X","1098-2795"],"issn-type":[{"value":"1040-452X","type":"print"},{"value":"1098-2795","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,14]]},"assertion":[{"value":"2019-04-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}