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CYP26B1 degrades retinoic acid in the testis during prenatal development preventing meiosis initiation. Given the concurrence of meiotic entry and completion of Sertoli cell maturation in response to androgens at puberty in the mouse, we proposed that CYP26B1 is downregulated by androgens in the Sertoli cell during this period. By immunohistochemistry, we showed that CYP26B1 declines in Sertoli cells after birth. However, luciferase reporter assays and quantitative reverse transcription\u2010polymerase chain reaction performed in the prepubertal mouse Sertoli cell line SMAT1 revealed no changes in <jats:italic>Cyp26b1<\/jats:italic> expression in response to androgen treatment. Furthermore, studies carried out using primary Sertoli cells of 10\u2010day\u2010old mice showed no changes in either <jats:italic>Cyp26b1<\/jats:italic> or CYP26B1 expression in response to androgen treatment. In summary, the hereby reported decline in CYP26B1 expression in Sertoli cells towards pubertal onset does not appear to be caused by a direct inhibitory effect of androgens on Sertoli cells in the mouse.<\/jats:p>","DOI":"10.1002\/mrd.23302","type":"journal-article","created":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T10:21:35Z","timestamp":1574418095000},"page":"66-77","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["CYP26B1 declines postnatally in Sertoli cells independently of androgen action in the mouse testis"],"prefix":"10.1002","volume":"87","author":[{"given":"Nadia Y.","family":"Edelsztein","sequence":"first","affiliation":[{"name":"Centro de Investigaciones Endocrinol\u00f3gicas \u201cDr. C\u00e9sar Bergad\u00e1\u201d (CEDIE), CONICET \u2013 FEI \u2013 Divisi\u00f3n de Endocrinolog\u00eda Hospital de Ni\u00f1os Ricardo Guti\u00e9rrez  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Kashimada","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Developmental Biology Tokyo Medical and Dental University (TMDU)  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena F.","family":"Schteingart","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Endocrinol\u00f3gicas \u201cDr. C\u00e9sar Bergad\u00e1\u201d (CEDIE), CONICET \u2013 FEI \u2013 Divisi\u00f3n de Endocrinolog\u00eda Hospital de Ni\u00f1os Ricardo Guti\u00e9rrez  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1100-3843","authenticated-orcid":false,"given":"Rodolfo A.","family":"Rey","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Endocrinol\u00f3gicas \u201cDr. C\u00e9sar Bergad\u00e1\u201d (CEDIE), CONICET \u2013 FEI \u2013 Divisi\u00f3n de Endocrinolog\u00eda Hospital de Ni\u00f1os Ricardo Guti\u00e9rrez  Buenos Aires Argentina"},{"name":"Departamento de Biolog\u00eda Celular, Histolog\u00eda, Embriolog\u00eda y Gen\u00e9tica, Facultad de Medicina Universidad de Buenos Aires  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,22]]},"reference":[{"issue":"11","key":"e_1_2_7_2_1","first-page":"511","article-title":"Plasma inhibin B and antim\u00fcllerian hormone concentrations in boys: Discriminating between congenital hypogonadotropic hypogonadism and constitutional pubertal delay","volume":"16","author":"Adan L.","year":"2010","journal-title":"Medical Science Monitor"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119653"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1919"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.pdr.0000246072.04663.bb"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1909"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1125691"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.135.3.8070367"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0307306101"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0915"},{"issue":"45","key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"28314","DOI":"10.1016\/S0021-9258(18)46930-X","article-title":"The purification, cloning, and expression of a novel luteinizing hormone\u2010induced mitochondrial protein in MA\u201010 mouse Leydig tumor cells. 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