{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:36:45Z","timestamp":1791902205496,"version":"4.3.4"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,1,12]],"date-time":"2020-01-12T00:00:00Z","timestamp":1578787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Reproduction Devel"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Male infertility is a rising problem around the world. Often the cause of male infertility is unclear, and this hampers diagnosis and treatment. Spermatogenesis is a complex process under sophisticated regulation by many testis\u2010specific genes. Here, we report the testis\u2010specific gene <jats:italic>1700102P08Rik<\/jats:italic> is conserved in both the human and mouse and highly expressed in spermatocytes. To investigate the role of <jats:italic>1700102P08Rik<\/jats:italic> in male fertility, knockout mice were generated by CRISPR\u2010Cas9. <jats:italic>1700102P08Rik<\/jats:italic> knockout male mice were infertile with smaller testis and epididymis, but female knockout mice retained normal fertility. Spermatogenesis in the <jats:italic>1700102P08Rik<\/jats:italic> knockout male mouse was arrested at the spermatocyte stage, and no sperm were found in the epididymis. The deletion of <jats:italic>1700102P08Rik<\/jats:italic> causes apoptosis in the testis but did not affect the serum concentration of testosterone, luteinizing hormone, and follicle\u2010stimulating hormone or the synapsis and recombination of homologous chromosomes. We also found that 1700102P08Rik is downregulated in spermatocyte arrest in men. Together, these results indicate that the <jats:italic>1700102P08Rik<\/jats:italic> gene is essential for spermatogenesis and its dysfunction leads to male infertility.<\/jats:p>","DOI":"10.1002\/mrd.23314","type":"journal-article","created":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T05:00:18Z","timestamp":1578891618000},"page":"231-240","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The testis\u2010specific gene <i>1700102P08Rik<\/i> is essential for male fertility"],"prefix":"10.1002","volume":"87","author":[{"given":"Xiao\u2010Long","family":"Wu","sequence":"first","affiliation":[{"name":"Medical School, Institute of Reproductive Medicine Nantong University Nantong Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da\u2010Min","family":"Yun","sequence":"additional","affiliation":[{"name":"Medical School, Institute of Reproductive Medicine Nantong University Nantong Jiangsu 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