{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T12:39:39Z","timestamp":1754483979043,"version":"3.37.3"},"reference-count":58,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,3,22]],"date-time":"2020-03-22T00:00:00Z","timestamp":1584835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007165","name":"University of Missouri","doi-asserted-by":"publisher","award":["Research Council Grant"],"award-info":[{"award-number":["Research Council Grant"]}],"id":[{"id":"10.13039\/100007165","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Reproduction Devel"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We conducted an integrated analysis of gene expression and chromatin structure of mouse uterus to understand the regulation of uterine\u2010expressed genes on gestation day 4 (GD4) during the peri\u2010implantation period. The genes expressed in the uterus showed a significant association (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001) with the presence of the nucleosome\u2010free region (open chromatin) in the 5\u2032\u2010untranslated region of the genes. The majority of these upstream open chromatins harbored a common class of regulatory elements known as upstream open reading frames. We also compared the gene expression profiles between the uterus and brain which showed that specific gene pairs were expressed in a correlated manner, either positively or negatively. In addition, specific ligand\/receptor genes showed coordinated patterns of expression between the uterus and brain on GD4, and the level of expression of these ligand\/receptors altered significantly in the brain during late pregnancy (GD15) compared with the peri\u2010implantation period (GD4). Collectively, these results suggest that regulation of the uterine genes during the peri\u2010implantation period is likely to have a functional link with the maternal brain in pregnant mice.<\/jats:p>","DOI":"10.1002\/mrd.23338","type":"journal-article","created":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T06:20:09Z","timestamp":1584944409000},"page":"482-492","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Regulation of uterine genes during the peri\u2010implantation period, and its relationship to the maternal brain in gestating mice"],"prefix":"10.1002","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1057-2435","authenticated-orcid":false,"given":"Susanta K.","family":"Behura","sequence":"first","affiliation":[{"name":"Division of Animal Sciences University of Missouri Columbia Missouri"},{"name":"Institute for Data Science and Informatics University of Missouri Columbia Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew M.","family":"Kelleher","sequence":"additional","affiliation":[{"name":"Division of Animal Sciences University of Missouri Columbia Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2815-766X","authenticated-orcid":false,"given":"Thomas E.","family":"Spencer","sequence":"additional","affiliation":[{"name":"Division of Animal Sciences University of Missouri Columbia Missouri"},{"name":"Department of Obstetrics, Gynecology and Women's Health University of Missouri Columbia Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00758-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612053381684"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000096887"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003529"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00037"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104468"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201802037R"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-016-2468-x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2014.11.008"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5487.2122"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0810916106"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1306301"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-3019(97)00193-6"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007570509232"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-237446"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12177"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/biolreprod\/20.1.111"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp902"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.891101"},{"key":"e_1_2_7_21_1","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S0021-9258(18)54212-5","article-title":"Cell\u2010specific translational regulation of S\u2010adenosylmethionine decarboxylase mRNA. 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