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CLU, as one of the crucial seminal plasma glycoproteins, plays a very important role in sperm capacitation and immune tolerance in the female reproductive tract. CLU is also known as a sensitive marker of oxidative stress. It has six <jats:sc>n<\/jats:sc>\u2010glycosylation sites and also exhibits chaperone activity. An analysis of changes in the profile and degree of CLU glycosylation may shed some new light on the molecular mechanisms of the fertilization process and may be used as an additional diagnostic marker of male fertility. This study constitutes a review of the recently available literature concerning human seminal CLU, including changes in its glycosylation, analyzed in the context of human reproduction.<\/jats:p>","DOI":"10.1002\/mrd.23340","type":"journal-article","created":{"date-parts":[[2020,3,28]],"date-time":"2020-03-28T08:20:53Z","timestamp":1585383653000},"page":"515-524","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Could the glycosylation analysis of seminal plasma clusterin become a novel male infertility biomarker?"],"prefix":"10.1002","volume":"87","author":[{"given":"Ewa","family":"Janiszewska","sequence":"first","affiliation":[{"name":"Department of Laboratory Diagnostics, Division of Laboratory Diagnostics Faculty of Pharmacy  Wroclaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2948-4574","authenticated-orcid":false,"given":"Ewa Maria","family":"Kratz","sequence":"additional","affiliation":[{"name":"Department of Laboratory Diagnostics, Division of Laboratory Diagnostics Faculty of Pharmacy  Wroclaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)32238-5"},{"issue":"1733","key":"e_1_2_9_3_1","first-page":"1","article-title":"Immunity to \u03b1\u2010Gal: The opportunity for malaria and tuberculosis control","volume":"8","author":"Cabezas\u2010Cruz A.","year":"2017","journal-title":"Frontiers in Immunology"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M111.008730"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/1008-682X.164924"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2014.74"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2009.136333"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/1354750X.2012.719035"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod28.5.1173"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.12558"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-19-0060"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.108.075739"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-012-9779-x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-015-0465-7"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.2000.tb03419.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmv016"},{"key":"e_1_2_9_17_1","doi-asserted-by":"crossref","first-page":"11030","DOI":"10.1016\/S0021-9258(18)99123-4","article-title":"Clusterin (complement lysis inhibitor) forms a high density lipoprotein complex with apolipoprotein A\u2010I in human plasma","volume":"266","author":"Jenne D. 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