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However, the functional role of Haprin is poorly understood. The aim of this study was to investigate the physiological role of Haprin in fertility. Homozygous <jats:italic>haprin<\/jats:italic>\u2010deficient mice were generated and these mice, and their spermatozoa, were analyzed to detect morphological and fertility\u2010related abnormalities. In these models, normal spermatogenesis was observed but sperm quality was reduced with <jats:italic>haprin<\/jats:italic>\u2010deficient mice having poorer sperm morphology and motility than wild\u2010type mice. Interestingly, <jats:italic>haprin<\/jats:italic>\u2010deficient mice showed normal in vivo fertility but could not fertilize oocytes under standard in vitro fertilization conditions. In conclusion, this study demonstrated that Haprin deficiency causes morphological abnormalities in spermatozoa, indicating that Haprin is involved in spermiogenesis.<\/jats:p>","DOI":"10.1002\/mrd.23344","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T17:26:23Z","timestamp":1587403583000},"page":"534-541","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["<i>Haprin<\/i>\u2010deficient spermatozoa are incapable of in vitro fertilization"],"prefix":"10.1002","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8636-4491","authenticated-orcid":false,"given":"Yusuke","family":"Aoki","sequence":"first","affiliation":[{"name":"Department of Urology Juntendo University Urayasu Hospital  Urayasu Chiba Japan"},{"name":"Department of Urology Juntendo University Graduate School of Medicine  Bunkyo\u2010ku 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