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Aberrant expression of proinflammatory cytokines during pregnancy contributes towards preterm labor, pre\u2010eclampsia, and gestational diabetes mellitus. The regulation of cytokine expression in human cells is highly complex, involving interactions between environment, transcription factors, and feedback mechanisms. Recent developments in epigenetic research have made tremendous advancements in exploring histone modifications as a key epigenetic regulator of cytokine expression and the effect of their signaling molecules on various organ systems in the human body. Histone acetylation and subsequent deacetylation by histone deacetylases (HDACs) are major epigenetic regulators of protein expression in the human body. The expression of various proinflammatory cytokines, their role in normal and abnormal pregnancy, and their epigenetic regulation via HDACs will be discussed in this review.<\/jats:p>","DOI":"10.1002\/mrd.23430","type":"journal-article","created":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T06:34:50Z","timestamp":1619505290000},"page":"321-337","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Cytokines and pregnancy: Potential regulation by histone\u00a0deacetylases"],"prefix":"10.1002","volume":"88","author":[{"given":"Sheryl K.","family":"Munro","sequence":"first","affiliation":[{"name":"Liggins Institute The University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7178-4787","authenticated-orcid":false,"given":"Biju","family":"Balakrishnan","sequence":"additional","affiliation":[{"name":"Liggins Institute The University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbey C.","family":"Lissaman","sequence":"additional","affiliation":[{"name":"Liggins Institute The University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palak","family":"Gujral","sequence":"additional","affiliation":[{"name":"Liggins Institute The University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3834-359X","authenticated-orcid":false,"given":"Anna P.","family":"Ponnampalam","sequence":"additional","affiliation":[{"name":"Liggins Institute The University of Auckland Auckland New Zealand"},{"name":"Department of Physiology, Faculty of Medicine and Health Sciences University of Auckland Auckland New Zealand"},{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.104.030841"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0404429101"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.04.021"},{"issue":"2","key":"e_1_2_7_5_1","first-page":"99","article-title":"DNA packaging: Nucleosomes and chromatin","volume":"55","author":"Annunziato A. 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