{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T04:25:06Z","timestamp":1745814306677},"reference-count":6,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T00:00:00Z","timestamp":1617667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Reproduction Devel"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Intraflagellar transport 27 (IFT27) is a key regulator for spermiogenesis and male fertility in mice. ATP8a1, a protein involved in the translocation of phosphatidylserine and phosphatidylethanolamine across lipid bilayers, is the strongest binding partner of IFT27. To investigate the role of ATP8a1 in spermatogenesis and male fertility, the global <jats:italic>Atp8a1<\/jats:italic> knockout mice were analyzed. All mutant mice were fertile, and sperm count and motility were comparable to the control mice. Examination of testis and epididymis by hematoxylin and eosin staining did not reveal major histologic defects. These observations demonstrate that ATP8a1 is not a major spermatogenesis regulator. Given that a tissue\u2010specific paralogue of ATP8a1, ATP8a2, is present, further studies with double\u2010knockout models are warranted to delineate any compensatory functions of the two proteins.<\/jats:p>","DOI":"10.1002\/mrd.23470","type":"journal-article","created":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T07:18:16Z","timestamp":1617693496000},"page":"371-375","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["ATP8a1, an IFT27 binding partner, is dispensable for spermatogenesis and male fertility"],"prefix":"10.1002","volume":"88","author":[{"given":"Yi T.","family":"Yap","sequence":"first","affiliation":[{"name":"Department of Physiology Wayne State University Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu H.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Physiology Wayne State University Detroit Michigan USA"},{"name":"School of Public Health Wuhan University of Science and Technology Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Physiology Wayne State University Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Probal","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Chemistry The College of Staten Island (CUNY) Staten Island New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhibing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Physiology Wayne State University Detroit Michigan USA"},{"name":"Department of Obstetrics &amp; Gynecology Wayne State University Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,6]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2011.07543.x"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.182.5.1545"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/JRLCR.S3773"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpbi.5"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2017.09.023"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002853"}],"container-title":["Molecular Reproduction and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrd.23470","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mrd.23470","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrd.23470","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T19:52:57Z","timestamp":1693425177000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrd.23470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,6]]},"references-count":6,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1002\/mrd.23470"],"URL":"https:\/\/doi.org\/10.1002\/mrd.23470","archive":["Portico"],"relation":{},"ISSN":["1040-452X","1098-2795"],"issn-type":[{"value":"1040-452X","type":"print"},{"value":"1098-2795","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,6]]},"assertion":[{"value":"2020-12-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}